A Rationally Designed Building Block of the Putative Magnetoreceptor MagR

doi:10.1002/bem.22413

	A Rationally Designed Building Block of the Putative Magnetoreceptor MagR
	Yang, Peilin 1; Cai, Tiantian 1; Zhang, Lei 2; Yu, Daqi 3; Guo, Zhen 1; Zhang, Yuebin 4; Li, Guohui 4; Zhang, Xin 2,5; Xie, Can 1,2,5,6
刊名	BIOELECTROMAGNETICS
	2022-07-01
卷号	43
关键词	magnetoreception MagR rational design single-chain-tetramer building block
ISSN号	0197-8462
DOI	10.1002/bem.22413
通讯作者	Zhang, Xin(xinzhang@hmfl.ac.cn) ; Xie, Can(canxie@hmfl.ac.cn)
英文摘要	The ability of animals to perceive guidance cues from Earth's magnetic field for orientation and navigation has been supported by a wealth of behavioral experiments, yet the nature of this sensory modality remains fascinatingly unresolved and wide open for discovery. MagR has been proposed as a putative magnetoreceptor based on its intrinsic magnetism and its complexation with a previously suggested key protein in magnetosensing, cryptochrome, to form a rod-like polymer structure. Here, we report a rationally designed single-chain tetramer of MagR (SctMagR), serving as the building block of the hierarchical assembly of MagR polymer. The magnetic trapping experiment and direct magnetic measurement of SctMagR demonstrated the possibility of magnetization of nonmagnetic cells via overexpressing a single protein, which has great potential in various applications. SctMagR, as reported in this study, serves as a prototype of designed magnetic biomaterials inspired by animal magnetoreception. The features of SctMagR provide insights into the unresolved origin of the intrinsic magnetic moment, which is of considerable interest in both biology and physics. (c) 2022 Bioelectromagnetics Society.
资助项目	Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences[BJZX201901] ; HFIPS Director's Fund[YZJJZX202014] ; National Natural Science Foundation of China[31640001] ; National Natural Science Foundation of China[21625302] ; National Natural Science Foundation of China[31700647]
WOS关键词	MOLECULAR CHARACTERIZATION ; EXPRESSION PROFILES ; CRYSTAL-STRUCTURE ; ISCA ; PROTEIN ; CLUSTER ; ORIENTATION ; ANCIENT ; REVEALS ; BINDING
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Biophysics
语种	英语
出版者	WILEY
WOS记录号	WOS:000798526700001
资助机构	Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences ; HFIPS Director's Fund ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130925]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Xin; Xie, Can
作者单位	1.Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Lab Mol Biophys, Beijing, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Peoples R China 3.Peking Univ, Sch Phys, State Key Lab Artificial Microstruct & Mesoscop P, Beijing, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian, Peoples R China 5.Int Magnetobiol Frontier Res Ctr, Hefei, Peoples R China 6.China Acad Engn Phys, Beijing Computat Sci Res Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Peilin,Cai, Tiantian,Zhang, Lei,et al. A Rationally Designed Building Block of the Putative Magnetoreceptor MagR[J]. BIOELECTROMAGNETICS,2022,43.
APA	Yang, Peilin.,Cai, Tiantian.,Zhang, Lei.,Yu, Daqi.,Guo, Zhen.,...&Xie, Can.(2022).A Rationally Designed Building Block of the Putative Magnetoreceptor MagR.BIOELECTROMAGNETICS,43.
MLA	Yang, Peilin,et al."A Rationally Designed Building Block of the Putative Magnetoreceptor MagR".BIOELECTROMAGNETICS 43(2022).