Population Pharmacokinetics of Tacrolimus in Pediatric Patients With Umbilical Cord Blood Transplant

doi:10.1002/jcph.2162

	Population Pharmacokinetics of Tacrolimus in Pediatric Patients With Umbilical Cord Blood Transplant
	Zuo, Meiling 2; Shang, Yue 1,3; Guo, Ye 1,3; Sun, Yuxuan 2; Xu, Gaoqi 4; Chen, Jingtao 5; Zhu, Liqin 2,6
刊名	JOURNAL OF CLINICAL PHARMACOLOGY
	2022-11-14
ISSN号	0091-2700
DOI	10.1002/jcph.2162
通讯作者	Zhu, Liqin(30819327@nankai.edu.cn)
英文摘要	Tacrolimus was frequently used in pediatric patients with umbilical cord blood transplant for the prevention of graft-versus-host disease. The aim of the present study was to evaluate the population pharmacokinetics of tacrolimus among pediatric patients with umbilical cord blood transplant and find potential influenced factors. A total of 275 concentrations from 13 pediatric patients were used to build a polulation pharmacokinetic model using a nonlinear mixed-effects modeling approach. The impact of demographic features, biological characteristics, and concomitant medications, including sex, age, body weight, postoperative day, white blood cell count, red blood cell count, hemoglobin, platelets, hematocrit, blood urea nitrogen, creatinine, aspartate transaminase, alanine transaminase, total bilirubin, albumin, and total protein were investigated. The pharmacokinetics of tacrolimus were best described by a 1-compartment model with first- and zero-order mixed absorption and first-order elimination. The clearance and volume of distribution of tacrolimus were 1.93 L/h and 75.1 L, respectively. A covariate analysis identified that postoperative day and co-administration with trimethoprim-sulfamethoxazole were significant covariates influencing clearance of tacrolimus. Frequent blood monitoring and dose adjustment might be needed with the prolongation of postoperative day and coadministration with trimethoprim-sulfamethoxazole.
WOS关键词	CLINICAL PHARMACOKINETICS ; DRUG-INTERACTIONS ; PHARMACOGENETICS ; CYCLOSPORINE ; METABOLISM ; GUIDELINES ; DOSAGE ; MODEL ; FK506 ; PHARMACODYNAMICS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000883301200001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130331]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhu, Liqin
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol,Haihe Lab Cell Ecosyst, Tianjin, Peoples R China 2.Tianjin Med Univ, Pharmaceut Coll, Tianjin, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R China 4.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Hangzhou, Peoples R China 5.Nankai Univ, Sch Stat & Data Sci, Tianjin, Peoples R China 6.Tianjin First Cent Hosp, Dept Pharm, 24 Fukang Rd, Tianjin 300192, Peoples R China
推荐引用方式 GB/T 7714	Zuo, Meiling,Shang, Yue,Guo, Ye,et al. Population Pharmacokinetics of Tacrolimus in Pediatric Patients With Umbilical Cord Blood Transplant[J]. JOURNAL OF CLINICAL PHARMACOLOGY,2022.
APA	Zuo, Meiling.,Shang, Yue.,Guo, Ye.,Sun, Yuxuan.,Xu, Gaoqi.,...&Zhu, Liqin.(2022).Population Pharmacokinetics of Tacrolimus in Pediatric Patients With Umbilical Cord Blood Transplant.JOURNAL OF CLINICAL PHARMACOLOGY.
MLA	Zuo, Meiling,et al."Population Pharmacokinetics of Tacrolimus in Pediatric Patients With Umbilical Cord Blood Transplant".JOURNAL OF CLINICAL PHARMACOLOGY (2022).