Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study

doi:10.1016/j.jddst.2022.103771

	Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study
	Zong, Rui 4; Ruan, Hainan 4; Zhu, Wenzheng 5; Zhang, Peng 4; Feng, Zhaojun 4; Liu, Chanmin 4; Fan, Shaohua 4; Liang, Huamin 1,2,3,6; Li, Jun 4
刊名	JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
	2022-10-01
卷号	76
关键词	Nanocrystals Curcumin Antibacterial activity Surface charge Zeta potential
ISSN号	1773-2247
DOI	10.1016/j.jddst.2022.103771
通讯作者	Fan, Shaohua(fshfly@jsnu.edu.cn) ; Liang, Huamin(lianghm@hfcas.ac.cn) ; Li, Jun(lijun@jsnu.edu.cn)
英文摘要	Curcumin (CUR) is a natural polyphenol with broad-spectrum antimicrobial efficacy, however, its use has been limited by low water solubility and poor stability. The aim of this study was to develop CUR nanocrystals (NCs) to improve its water solubility and stability, and investigate the effect of surface charge on its antibacterial activity. CUR NCs were prepared with different ratios of Pluronic F127 (F127) and hexadecyl trimethyl ammonium bromide (CTAB) as stabilizers to achieve tunable surface charge. The mean particle sizes of CUR NCs were around 150 nm, and zeta potentials were varied from-16.7 to 36.5 mV. Solubility and stability of CUR were significantly enhanced by processing into NCs. In vitro dissolution test showed that the dissolution rate of CUR NC was significantly higher than free CUR. Compared with free CUR, CUR NCs displayed low cytotoxicity against normal human kidney-2 cells. Moreover, comprehensive experiments (MIC, MBC, zone of inhibition and colony counting method) all demonstrate that CUR NCs with high positive surface charge exhibited excellent antibacterial activity than free CUR against E. coli and S. aureus, and SEM images showed that CUR NCs could destroy the surface of the bacteria cell to enhance the antibacterial activity. The overall results suggest that the CUR NC may be a promising antibacterial agent for pharmaceutical application.
资助项目	Natural Science Foundation of Jiangsu Normal University[16XLR046] ; Postgraduate Research & Practice Innovation Program of Jiangsu Province[KYCX22_2808] ; Pri-ority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Leading Talent Program of Hefei[2018-1-006]
WOS关键词	ANTIINFLAMMATORY PROPERTIES ; ANTICANCER ; ANTIOXIDANT ; DELIVERY ; SYSTEM
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000860503400006
资助机构	Natural Science Foundation of Jiangsu Normal University ; Postgraduate Research & Practice Innovation Program of Jiangsu Province ; Pri-ority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Leading Talent Program of Hefei
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129169]
专题	中国科学院合肥物质科学研究院
通讯作者	Fan, Shaohua; Liang, Huamin; Li, Jun
作者单位	1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 2.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China 3.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei 230031, Peoples R China 4.Jiangsu Normal Univ, Sch Life Sci, Xuzhou 221116, Jiangsu, Peoples R China 5.Jiangsu Normal Univ, CW CHU Coll, Xuzhou 221116, Jiangsu, Peoples R China 6.Chinese Acad Sci, Inst Technol Innovat, Hefei Inst Phys Sci, Precis Targeted Therapy Discovery Ctr, Hefei 230088, Peoples R China
推荐引用方式 GB/T 7714	Zong, Rui,Ruan, Hainan,Zhu, Wenzheng,et al. Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2022,76.
APA	Zong, Rui.,Ruan, Hainan.,Zhu, Wenzheng.,Zhang, Peng.,Feng, Zhaojun.,...&Li, Jun.(2022).Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,76.
MLA	Zong, Rui,et al."Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 76(2022).