The critical components for effective adaptive radiotherapy in patients with unresectable non-small-cell lung cancer: who, when and how

doi:10.2217/fon-2022-0291

	The critical components for effective adaptive radiotherapy in patients with unresectable non-small-cell lung cancer: who, when and how
	Zhou, Suna 2,3; Meng, Yinnan 1,2; Sun, Xuefeng 1,2; Jin, Zhicheng 1,2; Feng, Wei 4; Yang, Haihua 1,2
刊名	FUTURE ONCOLOGY
	2022-10-03
关键词	ART how NSCLC when who
ISSN号	1479-6694
DOI	10.2217/fon-2022-0291
通讯作者	Yang, Haihua(yhh93181@163.com)
英文摘要	Adaptive radiotherapy (ART) is a new radiotherapy technology based on image-guided radiation therapy technology, used to avoid radiation overexposure to residual tumors and the surrounding normal tissues. Tumors undergoing the same radiation doses and modes can occur unequal shrinkage due to the variation of response times to radiation doses in different patients. To perform ART effectively, eligible patients with a high probability of benefits from ART need to be identified. Confirming the precise timetable for ART in every patient is another urgent problem to be resolved. Moreover, the outcomes of ART are different depending on the various image guidance used. This review discusses 'who, when and how' as the three key factors involved in the most effective implementation for the management of ART. Plain language summary Adaptive radiotherapy (ART) is an image-guided radiotherapy technology used to treat tumors. This article explores who can gain more benefits from ART, when is the optimal time to conduct ART and how to better implement ART. Non-small-cell lung cancer patients with large tumor lesions and high radiosensitivity are the most suitable people for ART. The period of 30-50 Gy and 15-25 fractions of radiotherapy may be the most appropriate time for ART. All imaging guidances have their advantages and disadvantages. Although ART has more benefits, ART is not universally used in the clinic because of the associated labor, economic burden and need for equipment updating. This paper helps guide and popularize the application of the ART strategy in the clinic within economic benefits and feasibility.
资助项目	National Natural Science Foundation of China[NSFC 81872458] ; Open project of Zhejiang Key Laboratory of Radiation Oncology[2022ZJCCRAD03]
WOS关键词	RADIATION-THERAPY ; TUMOR VOLUME ; CONFORMAL RADIOTHERAPY ; RESPIRATORY MOTION ; ANATOMICAL CHANGES ; DOSE-ESCALATION ; TOMOGRAPHY ; CHEMORADIATION ; CONSOLIDATION ; LYMPHOPENIA
WOS研究方向	Oncology
语种	英语
出版者	FUTURE MEDICINE LTD
WOS记录号	WOS:000862882800001
资助机构	National Natural Science Foundation of China ; Open project of Zhejiang Key Laboratory of Radiation Oncology
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129115]
专题	中国科学院合肥物质科学研究院
通讯作者	Yang, Haihua
作者单位	1.Wenzhou Med Univ, Affiliated Taizhou Hosp, Dept Radiat Oncol, Taizhou 317000, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Affiliated Taizhou Hosp, Key Lab Radiat Oncol, Taizhou 317000, Zhejiang, Peoples R China 3.Northwest Univ, Xian 3 Hosp, Dept Radiat Oncol, Affiliated Hosp, Xian 710018, Shanxi, Peoples R China 4.Univ Chinese Acad Sci, Dept Radiat Oncol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou 310022, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Suna,Meng, Yinnan,Sun, Xuefeng,et al. The critical components for effective adaptive radiotherapy in patients with unresectable non-small-cell lung cancer: who, when and how[J]. FUTURE ONCOLOGY,2022.
APA	Zhou, Suna,Meng, Yinnan,Sun, Xuefeng,Jin, Zhicheng,Feng, Wei,&Yang, Haihua.(2022).The critical components for effective adaptive radiotherapy in patients with unresectable non-small-cell lung cancer: who, when and how.FUTURE ONCOLOGY.
MLA	Zhou, Suna,et al."The critical components for effective adaptive radiotherapy in patients with unresectable non-small-cell lung cancer: who, when and how".FUTURE ONCOLOGY (2022).