The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer

doi:10.1177/15330338221117402

	The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer
	Chen, Keyu 1,2; Wu, Jiayi 1,2; Fang, Ziru 1,2; Shao, Xiying 1; Wang, Xiaojia 1
刊名	TECHNOLOGY IN CANCER RESEARCH & TREATMENT
	2022-09-01
卷号	21
关键词	early-stage breast cancer genomic expression profiles Oncotype DX MammaPrint RecurIndex prediction tools
ISSN号	1533-0346
DOI	10.1177/15330338221117402
通讯作者	Wang, Xiaojia(wxiaojia0803@163.com)
英文摘要	Breast cancer is a kind of malignant tumor that seriously endangers women's life and health. Once diagnosed, most patients will receive a combination of treatments to achieve a cure. However, breast cancer is a heterogeneous disease. Even with the same clinical stage and pathological features, its response to treatment and postoperative recurrence risk may still be completely different. With the advent of genomic assay, some patients with early-stage breast cancer who originally needed treatment can still achieve long-term disease-free survival without adjuvant chemotherapy, so as to achieve personalized and accurate treatment mode to a certain extent. In this paper, we reviewed the 5 most widely used and studied genomic panel technologies in breast cancer, namely Oncotype DX, MammaPrint, RecurIndex, PAM50, and EndoPredict, according to accessibility and availability. Based on the results of the completed or ongoing clinical studies, we summarized the origin, applicable population, and clinical efficacy of each detection method, and discussed the potential development prospect of detection technology in the future.
资助项目	National Key research and development program/International cooperation in science and technology innovation[2019YFE0196500] ; Key research and development projects in Zhejiang Province/International cooperation technology research and development and demonstration promotion projects[2020C04012]
WOS关键词	21-GENE RECURRENCE SCORE ; LATE DISTANT RECURRENCE ; CARCINOMA IN-SITU ; PAM50 RISK ; GENE-EXPRESSION ; LOCOREGIONAL RECURRENCE ; POSTMENOPAUSAL WOMEN ; INTRINSIC SUBTYPES ; ENDOCRINE THERAPY ; NEOADJUVANT CHEMOTHERAPY
WOS研究方向	Oncology
语种	英语
出版者	SAGE PUBLICATIONS INC
WOS记录号	WOS:000856112700001
资助机构	National Key research and development program/International cooperation in science and technology innovation ; Key research and development projects in Zhejiang Province/International cooperation technology research and development and demonstration promotion projects
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128980]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang, Xiaojia
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp,Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Zhejiang Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Chen, Keyu,Wu, Jiayi,Fang, Ziru,et al. The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer[J]. TECHNOLOGY IN CANCER RESEARCH & TREATMENT,2022,21.
APA	Chen, Keyu,Wu, Jiayi,Fang, Ziru,Shao, Xiying,&Wang, Xiaojia.(2022).The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer.TECHNOLOGY IN CANCER RESEARCH & TREATMENT,21.
MLA	Chen, Keyu,et al."The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer".TECHNOLOGY IN CANCER RESEARCH & TREATMENT 21(2022).