Biocompatible Ferrofluid Robot With Photothermal Property for Targeted Tumor Therapy

doi:10.1109/LRA.2022.3201696

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Biocompatible Ferrofluid Robot With Photothermal Property for Targeted Tumor Therapy
	Ji, Yiming 3; Bai, Xue 3; Sun, Hongyan 3; Wang, Luyao 3; Xu, Junjie 3; Gan, Chunyuan 3; Dai, Yuguo 3; Hui, Hui 1,4; Feng, Lin 2
刊名	IEEE ROBOTICS AND AUTOMATION LETTERS
	2022-10-01
卷号	7 期号:4 页码:11517-11522
关键词	Soft robot materials and design soft robot applications medical robots and systems
ISSN号	2377-3766
DOI	10.1109/LRA.2022.3201696
通讯作者	Feng, Lin(linfeng@buaa.edu.cn)
英文摘要	Magnetic-controlled micro-robots have promising applications in disease therapy due to their high targetability and drug utilization. Due to their unique deformable and divisible properties, ferrofluid robots have gained much attention in microchemical reaction chips and micromanipulation. This letter proposes a biocompatible ferrofluid robot and validates its potential to achieve targeted drug delivery and tumor cell killing. This biocompatible ferrofluidic robot contains 10 nm oleic acid-coated ferric tetroxide particles and vegetable oil and has good magnetic responsiveness, deformability, and photothermal properties, and can move in liquid environments such as blood. It can achieve motion with an error of less than 0.4 mm under closed-loop control and obstacle overturning and passage through narrow channels less than twice its diameter. In addition, the biocompatible ferrofluid robot can kill tumor cells in the target area due to the photothermal properties of the magnetic particles, and experimental results show that the tumor cell death rate can reach 95%. These capabilities give the biocompatible ferrofluid robot a significant advantage in getting the target location for cancer treatment through the vascular environment.
资助项目	National Key R&D Program of China[2019YFB1309700] ; Beijing Nova Program of Science and Technology[Z191100001119003]
WOS研究方向	Robotics
语种	英语
出版者	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
WOS记录号	WOS:000850870500004
资助机构	National Key R&D Program of China ; Beijing Nova Program of Science and Technology
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50107]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Feng, Lin
作者单位	1.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 2.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Sch Mech Engn & Amp Automat, Beijing 100083, Peoples R China 3.Beihang Univ, Sch Mech Engn & Amp Automat, Beijing 100191, Peoples R China 4.Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ji, Yiming,Bai, Xue,Sun, Hongyan,et al. Biocompatible Ferrofluid Robot With Photothermal Property for Targeted Tumor Therapy[J]. IEEE ROBOTICS AND AUTOMATION LETTERS,2022,7(4):11517-11522.
APA	Ji, Yiming.,Bai, Xue.,Sun, Hongyan.,Wang, Luyao.,Xu, Junjie.,...&Feng, Lin.(2022).Biocompatible Ferrofluid Robot With Photothermal Property for Targeted Tumor Therapy.IEEE ROBOTICS AND AUTOMATION LETTERS,7(4),11517-11522.
MLA	Ji, Yiming,et al."Biocompatible Ferrofluid Robot With Photothermal Property for Targeted Tumor Therapy".IEEE ROBOTICS AND AUTOMATION LETTERS 7.4(2022):11517-11522.