Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents

doi:10.1017/S0033291720002962

	Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents
	Li, Jin 16,17; Liu, Bing 7,8,16,17; Banaschewski, Tobias 23; Bokde, Arun L. W.9,10; Quinlan, Erin Burke 11; Desrivieres, Sylvane 11; Flor, Herta 12,13; Frouin, Vincent 14; Garavan, Hugh 15,18; Gowland, Penny 19
刊名	PSYCHOLOGICAL MEDICINE
	2022-04-01
卷号	52 期号:6 页码:1175-1182
关键词	Cortical volume orbitofrontal cortex polygenic risk score smoking tobacco use
ISSN号	0033-2917
DOI	10.1017/S0033291720002962
通讯作者	Schumann, Gunter(gunter.schumann@kcl.ac.uk) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要	Background Tobacco smoking remains one of the leading causes of preventable illness and death and is heritable with complex underpinnings. Converging evidence suggests a contribution of the polygenic risk for smoking to the use of tobacco and other substances. Yet, the underlying brain mechanisms between the genetic risk and tobacco smoking remain poorly understood. Methods Genomic, neuroimaging, and self-report data were acquired from a large cohort of adolescents from the IMAGEN study (a European multicenter study). Polygenic risk scores (PGRS) for smoking were calculated based on a genome-wide association study meta-analysis conducted by the Tobacco and Genetics Consortium. We examined the interrelationships among the genetic risk for smoking initiation, brain structure, and the number of occasions of tobacco use. Results A higher smoking PGRS was significantly associated with both an increased number of occasions of tobacco use and smaller cortical volume of the right orbitofrontal cortex (OFC). Furthermore, reduced cortical volume within this cluster correlated with greater tobacco use. A subsequent path analysis suggested that the cortical volume within this cluster partially mediated the association between the genetic risk for smoking and the number of occasions of tobacco use. Conclusions Our data provide the first evidence for the involvement of the OFC in the relationship between smoking PGRS and tobacco use. Future studies of the molecular mechanisms underlying tobacco smoking should consider the mediation effect of the related neural structure.
资助项目	National Key Basic Research and Development Program (973)[2011CB707800] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02030300] ; Natural Science Foundation of China[81000582] ; Natural Science Foundation of China[31300934] ; Natural Science Foundation of China[91132301] ; Natural Science Foundation of China[91232718] ; European Union[LSHM-CT-2007-037286] ; Horizon 2020[695313] ; ERANID (Understanding the Interplay between Cultural, Biological, and Subjective Factors in Drug Use Pathways)[PR-ST-041610004] ; BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics)[MR/N027558/1] ; Human Brain Project (HBP SGA 2)[785907] ; FP7 project MATRICS[603016] ; Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions)[MR/N000390/1] ; National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London ; Bundesministeriumfur Bildung und Forschung (BMBF)[01GS08152] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EV0711] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EE1406A] ; Bundesministeriumfur Bildung und Forschung (BMBF)[01EE1406B] ; Deutsche Forschungsgemeinschaft (DFG)[SM 80/7-2] ; Deutsche Forschungsgemeinschaft (DFG)[SFB 940] ; Deutsche Forschungsgemeinschaft (DFG)[TRR 265] ; Deutsche Forschungsgemeinschaft (DFG)[NE 1383/14-1] ; Medical Research Foundation ; Medical Research Council[MR/R00465X/1] ; Medical Research Council[MR/S020306/1] ; National Institutes of Health (NIH)[5U54EB020403-05] ; National Institutes of Health (NIH)[1R56AG058854-01] ; ANR[AF12-NEUR0008-01 -WM2NA] ; ANR[ANR-12-SAMA-0004] ; Eranet Neuron[ANR-18-NEUR00002-01] ; Fondation de France[00081242] ; Fondation pour la Recherche Medicale[DPA20140629802] ; Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA) ; Assistance-Publique-Hopitaux-de-Paris ; INSERM (interface grant) ; Paris Sud University IDEX 2012 ; fondation de l'Avenir[AP-RM-17-013] ; Federation pour la Recherche sur le Cerveau ; National Institutes of Health ; Science Foundation Ireland[16/ERCD/3797] ; U.S.A. (Axon, Testosterone and Mental Health during Adolescence)[RO1 MH085772-01A1] ; NIH Consortium grant - cross-NIH alliance[U54 EB020403]
WOS关键词	VENTROMEDIAL PREFRONTAL CORTEX ; SELF-REPORTED SMOKING ; CIGARETTE-SMOKING ; PRENATAL-EXPOSURE ; DECISION-MAKING ; METAANALYSIS ; NICOTINE ; IMPULSIVENESS ; ASSOCIATION ; VALIDATION
WOS研究方向	Psychology ; Psychiatry
语种	英语
出版者	CAMBRIDGE UNIV PRESS
WOS记录号	WOS:000849361300020
资助机构	National Key Basic Research and Development Program (973) ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Natural Science Foundation of China ; European Union ; Horizon 2020 ; ERANID (Understanding the Interplay between Cultural, Biological, and Subjective Factors in Drug Use Pathways) ; BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) ; Human Brain Project (HBP SGA 2) ; FP7 project MATRICS ; Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) ; National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London ; Bundesministeriumfur Bildung und Forschung (BMBF) ; Deutsche Forschungsgemeinschaft (DFG) ; Medical Research Foundation ; Medical Research Council ; National Institutes of Health (NIH) ; ANR ; Eranet Neuron ; Fondation de France ; Fondation pour la Recherche Medicale ; Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA) ; Assistance-Publique-Hopitaux-de-Paris ; INSERM (interface grant) ; Paris Sud University IDEX 2012 ; fondation de l'Avenir ; Federation pour la Recherche sur le Cerveau ; National Institutes of Health ; Science Foundation Ireland ; U.S.A. (Axon, Testosterone and Mental Health during Adolescence) ; NIH Consortium grant - cross-NIH alliance
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50017]
专题	自动化研究所_脑网络组研究中心
通讯作者	Schumann, Gunter; Jiang, Tianzi
作者单位	1.Free Univ Berlin, Berlin, Germany 2.Humboldt Univ, Berlin, Germany 3.Berlin Inst Hlth, Berlin, Germany 4.Phys Tech Bundesanstalt PTB, Braunschweig, Germany 5.Phys Tech Bundesanstalt PTB, Benin, Germany 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 7.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 8.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China 9.Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland 10.Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland
推荐引用方式 GB/T 7714	Li, Jin,Liu, Bing,Banaschewski, Tobias,et al. Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents[J]. PSYCHOLOGICAL MEDICINE,2022,52(6):1175-1182.
APA	Li, Jin.,Liu, Bing.,Banaschewski, Tobias.,Bokde, Arun L. W..,Quinlan, Erin Burke.,...&Jiang, Tianzi.(2022).Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents.PSYCHOLOGICAL MEDICINE,52(6),1175-1182.
MLA	Li, Jin,et al."Orbitofrontal cortex volume links polygenic risk for smoking with tobacco use in healthy adolescents".PSYCHOLOGICAL MEDICINE 52.6(2022):1175-1182.