Study on Antitumour Activity of Total Alkaloids of Cynanchum Komarovii in Vitro and in Vivo

	Study on Antitumour Activity of Total Alkaloids of Cynanchum Komarovii in Vitro and in Vivo
	Pu Xiuying; Wang Hengrui; Fan Wenbo; Yu Shuang
	2013
关键词	Total Alkaloids C.komarovii Anti-tumor MTT in vitro in vivo
页码	356-359
英文摘要	The antitumor activity of total alkaloids of C.komarovii (TAC) has not been previously examined in vitro and in vivo. In this study, MTT colorimetric method was used for determining the anti-tumor activity of TAC using HepG2 cells in vitro, and transplanted H22 hepatoma murine tumor models were employed to investigate the anti-tumor activity of TAC in vivo. The parameters for determining the anti-tumor efficacy included inhibition rate and half maximal inhibitory concentration (IC50) in vitro. The results showed that TAC could inhibit growth of HepG2 cells, and the inhibition efficacy exhibited dose dependence. TAC have inhibited tumor growth effectively, the inhibition rate of lower, middle and higher dose group of TAC were 13.28%, 28.13% and 39.06% respectively. Overall, these results indicate that the TAC has significant anti-tumor activity in vitro and in vivo.
会议录	PROCEEDINGS OF THE 2013 INTERNATIONAL CONFERENCE ON MATERIAL SCIENCE AND ENVIRONMENTAL ENGINEERING (MSEE 2013)
会议录出版者	DESTECH PUBLICATIONS, INC
会议录出版地	439 DUKE STREET, LANCASTER, PA 17602-4967 USA
语种	英语
WOS研究方向	Energy & Fuels ; Engineering ; Materials Science
WOS记录号	WOS:000324264500082
内容类型	会议论文
源URL	[http://119.78.100.223/handle/2XXMBERH/36960]
专题	生命科学与工程学院
通讯作者	Pu Xiuying
作者单位	Lanzhou Univ Technol, Life Sci & Engn Coll, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Pu Xiuying,Wang Hengrui,Fan Wenbo,et al. Study on Antitumour Activity of Total Alkaloids of Cynanchum Komarovii in Vitro and in Vivo[C]. 见:.