Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor

doi:10.1016/j.fitote.2014.07.022

	Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor
	Zhi, Kang-Kang 2; Yang, Zhong-Duo 2; Shi, Dan-Feng 1; Yao, Xiao-Jun 1; Wang, Ming-Gang 2
刊名	FITOTERAPIA
	2014-10
卷号	98 页码:160-165
关键词	Monoamine oxidase inhibitors Desmodium elegans Alkaloids Monoamine oxidase
ISSN号	0367-326X
DOI	10.1016/j.fitote.2014.07.022
英文摘要	Desmodeleganine (1), a new potential monoamine oxidase inhibitor, along with three known alkaloids, bufotenin (2), hydroxy-N, N-dimethyltryptamine N-12-oxide (3), 2-(5-methoxy-1H-indol-3-yl)-N, and N-dimethylethylamine (4) were isolated from the leaves of Desmodium elegans. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. 1 showed strong monoamine oxidase inhibitory activity with IC50 value of 13.92 +/- 1.5 mu M, when the IC50 value of iproniazid as a standard was 6.5 +/- 0.5 mu M. The molecular modeling was also performed to explore the binding mode of compounds 1, 2 at the active site of MAO-A and MAO-B. (C) 2014 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[21262022] ; Elitist Program of Lanzhou University of Technology[J201303]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000343617600023
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34278]
专题	生命科学与工程学院高等教育研究所（教学质量监督与评估工作办公室、本科教学督导委员会研究生督导委员会）
通讯作者	Yang, Zhong-Duo
作者单位	1.Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhi, Kang-Kang,Yang, Zhong-Duo,Shi, Dan-Feng,et al. Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor[J]. FITOTERAPIA,2014,98:160-165.
APA	Zhi, Kang-Kang,Yang, Zhong-Duo,Shi, Dan-Feng,Yao, Xiao-Jun,&Wang, Ming-Gang.(2014).Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor.FITOTERAPIA,98,160-165.
MLA	Zhi, Kang-Kang,et al."Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor".FITOTERAPIA 98(2014):160-165.