Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease

doi:10.1007/s00044-011-9582-8

	Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease
	Yang, Zhongduo 2; Zhang, Dongbo 2; Ren, Jin 2; Yang, Mingjun 2; Li, Shuo 1
刊名	MEDICINAL CHEMISTRY RESEARCH
	2012-06-01
卷号	21 期号:6 页码:734-738
关键词	Alzheimer's disease Acetylcholinesterase Alkaloid Ellman's method TLC bioautography Traditional Chinese herbal medicine
ISSN号	1054-2523
DOI	10.1007/s00044-011-9582-8
英文摘要	Alzheimer's disease (AD) is a progressive degenerative neurologic disorder resulting in impaired memory and behavior. A promising treatment strategy for AD has been the use of acetylcholinesterase (AChE) inhibitors. Several potent AChE inhibitors such as huperzine and galanthamine were originally isolated from plants, indicating that herbal medicines are a good source for the search of potential AChE inhibitors. In our study, to search for potential AChE inhibitors, the total alkaloidal extracts of 31 Chinese herbal medicines were tested for their AChE inhibitory activities by Ellman's method and modified TLC bioautographic assay. The results showed that the alkaloidal extracts of Uncaria rhynchophylla (Rubiaceae), Nelumbo nucifera (Nymphaeaceae), Zanthoxylum nitidum (Rutaceae), Portulaca oleracea (Portulacaceae), and Pinellia ternata (Araceae) exhibited remarkable AChE inhibitory activities at the final concentration of 100 mu g/ml. Their IC50 values were 10.8, 12.2, 17.4, 29.4, and 56.2 mu g/ml, respectively. The rest of the alkaloidal extracts showed no or very weak AChE inhibitory activities at the same concentration. The results of this study indicate that the screening of traditional Chinese herbs for AChE inhibitory activity may provide useful lead compounds in the discovery of new drugs for the treatment of AD.
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	BIRKHAUSER BOSTON INC
WOS记录号	WOS:000303471900007
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/155540]
专题	生命科学与工程学院
作者单位	1.Peking Univ, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China;
推荐引用方式 GB/T 7714	Yang, Zhongduo,Zhang, Dongbo,Ren, Jin,et al. Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease[J]. MEDICINAL CHEMISTRY RESEARCH,2012,21(6):734-738.
APA	Yang, Zhongduo,Zhang, Dongbo,Ren, Jin,Yang, Mingjun,&Li, Shuo.(2012).Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease.MEDICINAL CHEMISTRY RESEARCH,21(6),734-738.
MLA	Yang, Zhongduo,et al."Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer's disease".MEDICINAL CHEMISTRY RESEARCH 21.6(2012):734-738.