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Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi
Zhang, Xin-Guo; Peng, Yi-Nan; Li, Xiao-Ru; Ma, Guo-Di; Wang, Ming-Gang
刊名INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
2014
卷号84期号:5-6页码:277-285
关键词high-zinc-enriched fungi organic bound zinc bioavailability
ISSN号0300-9831
DOI10.1024/0300-9831/a000214
英文摘要The organic forms of trace elements are considered more bioavailable than the inorganic forms. Although yeast can enrich metal elements and convert inorganic zinc to organic species, its tolerability and transforming capacity are limited. It would therefore be very interesting to look for higher conversion and accumulation in zinc fungi to obtain organic bound zinc from the natural environment. In this paper, potato dextrose agar (PDA) medium containing 800 mu g/mL zinc was used for initial screening, with twenty-two fungal strains that tolerated high zinc isolated from the natural environment, and one strain (No.LZ-1108) growing well at a zinc (II) concentration of 10,000 mu g/mL. According to morphological analysis, 18S rDNA sequence analysis, and biophysical and biochemical characteristics, No.LZ-1108 was tentatively identified as Fusarium oxysporum. Using atomic absorption spectrometry, the zinc content in the No.LZ-1108 cells was found to be 6.7 mg/g dry cell. After oral administration to rats at a dose of 10 mg Zn (II)/kg body weight, the area under the plasma concentration-time curve (AUC) and the maximum zinc blood concentration (Cmax) of No.LZ-1108 and zinc gluconate were 8.10 g/L.min and 4.28 g/L.min, 23.72 mu g/mL and 6.23 mu g/mL, respectively. The AUC of No.LZ-1108 was significantly higher than those of zinc gluconate (P<0.05), and the mean relative bioavailability of AUC(test)/AUC(zinc gluconate) was 190 %, which showed that the bound zinc in No.LZ-1108 was more bioavailable than zinc gluconate. The present study reports an interesting alternative to developing zinc-based supplements from a natural source of zinc.
WOS研究方向Nutrition & Dietetics
语种英语
出版者VERLAG HANS HUBER
WOS记录号WOS:000359510100007
内容类型期刊论文
源URL[http://ir.lut.edu.cn/handle/2XXMBERH/155520]  
专题生命科学与工程学院
高等教育研究所(教学质量监督与评估工作办公室、本科教学督导委员会研究生督导委员会)
作者单位Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xin-Guo,Peng, Yi-Nan,Li, Xiao-Ru,et al. Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi[J]. INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH,2014,84(5-6):277-285.
APA Zhang, Xin-Guo,Peng, Yi-Nan,Li, Xiao-Ru,Ma, Guo-Di,&Wang, Ming-Gang.(2014).Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi.INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH,84(5-6),277-285.
MLA Zhang, Xin-Guo,et al."Higher Bioavailability of Organic Bound Zinc from High Zinc-Enriched Fungi".INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 84.5-6(2014):277-285.
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