Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor | |
Zhi, Kang-Kang2; Yang, Zhong-Duo2; Shi, Dan-Feng1; Yao, Xiao-Jun1; Wang, Ming-Gang2 | |
刊名 | FITOTERAPIA |
2014-10-01 | |
卷号 | 98页码:160-165 |
关键词 | Monoamine oxidase inhibitors Desmodium elegans Alkaloids Monoamine oxidase |
ISSN号 | 0367-326X |
DOI | 10.1016/j.fitote.2014.07.022 |
英文摘要 | Desmodeleganine (1), a new potential monoamine oxidase inhibitor, along with three known alkaloids, bufotenin (2), hydroxy-N, N-dimethyltryptamine N-12-oxide (3), 2-(5-methoxy-1H-indol-3-yl)-N, and N-dimethylethylamine (4) were isolated from the leaves of Desmodium elegans. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. 1 showed strong monoamine oxidase inhibitory activity with IC50 value of 13.92 +/- 1.5 mu M, when the IC50 value of iproniazid as a standard was 6.5 +/- 0.5 mu M. The molecular modeling was also performed to explore the binding mode of compounds 1, 2 at the active site of MAO-A and MAO-B. (C) 2014 Elsevier B.V. All rights reserved. |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000343617600023 |
内容类型 | 期刊论文 |
源URL | [http://ir.lut.edu.cn/handle/2XXMBERH/155511] |
专题 | 生命科学与工程学院 高等教育研究所(教学质量监督与评估工作办公室、本科教学督导委员会研究生督导委员会) |
作者单位 | 1.Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Peoples R China; |
推荐引用方式 GB/T 7714 | Zhi, Kang-Kang,Yang, Zhong-Duo,Shi, Dan-Feng,et al. Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor[J]. FITOTERAPIA,2014,98:160-165. |
APA | Zhi, Kang-Kang,Yang, Zhong-Duo,Shi, Dan-Feng,Yao, Xiao-Jun,&Wang, Ming-Gang.(2014).Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor.FITOTERAPIA,98,160-165. |
MLA | Zhi, Kang-Kang,et al."Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor".FITOTERAPIA 98(2014):160-165. |
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