Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil

doi:10.1177/1010428317711661

	Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil
	Zhang, Xin-Guo 1,2; Liu, Zi-Yu 1,2; Liu, Jin-Wen 1,2; Zeng, Yan-Long 1,2; Guo, Guang-Jun 1,2; Sun, Qiao-Yun 1,2
刊名	TUMOR BIOLOGY
	2017-06-22
卷号	39 期号:6
关键词	Actinomycetes polluted soil Rhodococcus sp antitumor activity
ISSN号	1010-4283
DOI	10.1177/1010428317711661
英文摘要	The actinomycetes strain, lut0910, was isolated from polluted soil and identified as the Rhodococcus species with 99% similarity based on the sequence analysis of 16S recombinant DNA. The extract of this strain demonstrated in vivo and in vitro antitumor activity. The treatment of two human cancer cell lines, hepatocellular carcinoma HepG2 and cervical carcinoma Hela cells, with the lut0910 extract caused the delay in cell propagation in a dose-dependent manner with an IC50 of 73.39 and 33.09 mu g/mL, respectively. Also, the oral administration of lut0910 extract to the mice with a solid tumor resulted in the inhibition of tumor growth in comparison with a placebo group. The thymus and spleen indexes were significantly increased in mice groups treated with the lut0910 extract. The histopathological changes of the tumor tissues showed that there were massive necrotic areas in the tumor tissues after treatment with different doses of the lut0910 extract. Our result would provide a new way and potent source for development of new anticancer agent from the polluted environment.
WOS研究方向	Oncology
语种	英语
出版者	SAGE PUBLICATIONS LTD
WOS记录号	WOS:000404157200001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/155429]
专题	生命科学与工程学院
作者单位	1.Key Lab Screening & Proc New Tibetan Med Gansu Pr, Gansu, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Xin-Guo,Liu, Zi-Yu,Liu, Jin-Wen,et al. Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil[J]. TUMOR BIOLOGY,2017,39(6).
APA	Zhang, Xin-Guo,Liu, Zi-Yu,Liu, Jin-Wen,Zeng, Yan-Long,Guo, Guang-Jun,&Sun, Qiao-Yun.(2017).Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil.TUMOR BIOLOGY,39(6).
MLA	Zhang, Xin-Guo,et al."Antitumor activity of a Rhodococcus sp Lut0910 isolated from polluted soil".TUMOR BIOLOGY 39.6(2017).