Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo

doi:10.1166/nnl.2020.3240

	Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo
	Liu, Bing 2; Ding, De 2; Zhao, Ping 2; Zhang, Xinguo 2; Tian, Zhenji 1; Xia, Xingxing 2; Zhang, Zihao 2
刊名	NANOSCIENCE AND NANOTECHNOLOGY LETTERS
	2020-11-01
卷号	12 期号:11 页码:1337-1343
关键词	Hirsutella sinensis Ghostmoth Mycelium Fermentation Immunomodulatory Activity
ISSN号	1941-4900
DOI	10.1166/nnl.2020.3240
英文摘要	In order to confirm whether HSFL (the fermented liquor of mycelia of Hirsutella sinensis) still contains cordycepin, Cordyceps polysaccharide and other functional components, and has the functions of anti-oxidation, tumor inhibition and immunity enhancement, the biological activity of HSFL in vivo and in vitro was studied in this study. The transformation ability of mouse spleen lymphocytes induced by ConA, the activity of NK cells in mouse spleen, the delayed allergic reaction induced by DNFB and the phagocytosis of chicken red cells by mouse peritoneal macrophages were studied. The results showed that when the concentration of HSFL was 0.5972 mg/kg and 1.1944 mg/kg, the transformation of lymphocytes induced by ConA and the activity of NK cells were significantly increased. HSFL also can significantly improve DNFB induced anaphylaxis in mice and phagocytosis of chicken erythrocytes by peritoneal macrophages in mice when the dose of HSFL is 50 mg/kg and 75 mg/kg, indicating that HSFL has the biological activity of enhancing immunity in vitro and in vivo.
WOS研究方向	Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000610459800012
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/155060]
专题	生命科学与工程学院
作者单位	1.Lanzhou Univ Technol, Sch Sci, Lanzhou 730050, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China;
推荐引用方式 GB/T 7714	Liu, Bing,Ding, De,Zhao, Ping,et al. Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo[J]. NANOSCIENCE AND NANOTECHNOLOGY LETTERS,2020,12(11):1337-1343.
APA	Liu, Bing.,Ding, De.,Zhao, Ping.,Zhang, Xinguo.,Tian, Zhenji.,...&Zhang, Zihao.(2020).Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo.NANOSCIENCE AND NANOTECHNOLOGY LETTERS,12(11),1337-1343.
MLA	Liu, Bing,et al."Evaluation of Immune Function of Mycelium Fermentation of Hirsutella sinensisin In Vitro and In Vivo".NANOSCIENCE AND NANOTECHNOLOGY LETTERS 12.11(2020):1337-1343.