Recent Advances in Patulin Biosynthesis and Its Molecular Regulation

doi:10.7506/spkx1002-6630-20190820-212

	Recent Advances in Patulin Biosynthesis and Its Molecular Regulation
	Wang, Yanling 1; Guo, Xiaojie 1; Zhang, Wenwei 2; Shang, Minmin 1; Zong, Yuanyuan 2; Bi, Yang 2
刊名	Shipin Kexue/Food Science
	2020-09-15
卷号	41 期号:17 页码:267-274
关键词	Biochemistry Cereal products Encoding (symbols) Enzymes Health risks Metabolites Molecules Transcription Biosynthesis pathways Biosynthetic pathway Filamentous fungi Genes encoding Molecular regulation Regulatory factors Secondary metabolites Transcriptional regulator
ISSN号	10026630
DOI	10.7506/spkx1002-6630-20190820-212
英文摘要	Patulin (PAT) is a toxic secondary metabolite produced by filamentous fungi such as Penicillium, Aspergillus and Byssochlamys, which poses a serious threat to human health. This article describes the patulin biosynthesis pathway, and its related genes and encoded enzymes as well as molecular regulation. Biosynthesis of PAT is determined by the patulin gene cluster (Pat) including 15 genes (PatA through PatO), which encodes catalytic enzymes, transcription factors and transporters involved in the biosynthesis pathway. The reaction starts from one molecule of acetyl-CoA and three molecules of malonyl-CoA to synthesize 6-methylsalicylic acid, which is decarboxylated and hydroxylated into gentisaldehyde, and then converted into isoepoxydon, phyllodin, E-ascladiol, and eventually patulin by a series of reactions. The biosynthetic pathway is not only regulated by the key genes encoding the catalytic enzymes, the specific transcriptional regulator (PatL), the global regulatory factors (LaeA, CreA and AreA), the pH-dependent regulatory factor (PacC), and the light regulatory factors (VeA and VelB), but also influenced by host factors. The aim of this paper is to provide a theoretical basis for the control and removal of patulin in cereals, vegetables, fruits and their products. © 2020, China Food Publishing Company. All right reserved.
语种	中文
出版者	Chinese Chamber of Commerce
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/150979]
专题	生命科学与工程学院
作者单位	1.School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou; 730050, China; 2.College of Food Science and Engineering, Gansu Agricultural University, Lanzhou; 730070, China
推荐引用方式 GB/T 7714	Wang, Yanling,Guo, Xiaojie,Zhang, Wenwei,et al. Recent Advances in Patulin Biosynthesis and Its Molecular Regulation[J]. Shipin Kexue/Food Science,2020,41(17):267-274.
APA	Wang, Yanling,Guo, Xiaojie,Zhang, Wenwei,Shang, Minmin,Zong, Yuanyuan,&Bi, Yang.(2020).Recent Advances in Patulin Biosynthesis and Its Molecular Regulation.Shipin Kexue/Food Science,41(17),267-274.
MLA	Wang, Yanling,et al."Recent Advances in Patulin Biosynthesis and Its Molecular Regulation".Shipin Kexue/Food Science 41.17(2020):267-274.