Antitumor activity of different fractions of Cynanchum komarocii in vitro

doi:10.2495/HHME130432

	Antitumor activity of different fractions of Cynanchum komarocii in vitro
	Pu, Xiuying; Wang, Hengrui; Yu, Shuang; Fan, Wenbo
	2014
会议日期	December 7, 2013 - December 8, 2013
会议地点	Wuhan, China
关键词	Biomedical engineering Anti-tumor activities Anti-tumors Cynanchum komarocii Ethanol extract In-vitro MTT Petroleum ether Proliferation inhibition
卷号	18
DOI	10.2495/HHME130432
页码	731-735
英文摘要	The antitumor activity of Cynanchum komarovii has not been previously examined in vitro system. The aim of this study was to evaluate the antitumor potential of C. komarovii by studying in vitro antitumor activity of the different fractions extract. The proliferation inhibition rate and IC50 of HepG2 cells in vitro were investigated by the MTT assay of the different fractions of C. komarovii. Our study revealed that the petroleum ether, chloroform, ethyl acetate, acetone, and 70% ethanol extract of C. komarovii showed significant antitumor activity towards HepG2 cells, and the proliferation inhibition rates, respectively were 63.84%, 64.18%, 63.00%, 74.80%, and 59.60% in the 1000 μg/mL of extract and the IC50 values were 459.88, 388.87, 399.27, 196.66, and 289.17 μg/mL, respectively. It indicated that acetone parts had better inhibit growth effect on HepG2 cells. © 2014 WIT Press.
会议录	WIT Transactions on Biomedicine and Health
会议录出版者	WITPress
语种	英语
ISSN号	17433525
内容类型	会议论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/117371]
专题	生命科学与工程学院
作者单位	Life Science and Engineering College, Lanzhou University of Technology, Lanzhou, China
推荐引用方式 GB/T 7714	Pu, Xiuying,Wang, Hengrui,Yu, Shuang,et al. Antitumor activity of different fractions of Cynanchum komarocii in vitro[C]. 见:. Wuhan, China. December 7, 2013 - December 8, 2013.