Total synthesis of the active cyclodepsipeptides Paecilodepsipeptide A

	Total synthesis of the active cyclodepsipeptides Paecilodepsipeptide A
	Yang, Ming-Jun 1; Li, Juan 1; Wang, Yong-Gang 1; Wu, Jing 2; Zhang, Fei 1; Yang, Zhong-Duo 1; Zhang, Ying-Mei 3
刊名	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
	2013-07-01
卷号	33 期号:7 页码:765-770
关键词	Amino acids Esterification Esters Nuclear magnetic resonance spectroscopy Raw materials Synthesis (chemical) Anti-tumor activities Cyclodepsipeptides Cyclopeptides Esterification reactions Natural products Paecilodepsipeptide A Peptide synthesis Total synthesis
ISSN号	10010645
英文摘要	Paecilodepsipeptide A isolated from Paecilomyces cinnamomeus BCC 9616 was first synthesized by retrosynthesis method, which shows good antimalarial and antitumor activity. Pentapeptide was synthesized by standard peptide synthesis method at first. Then, O-isopentenyl-D-tyrosine derivatives were obtained by using tyrosine methyl ester hydrochloride as the raw material. The cyclization precursors were obtained by esterification reaction between the pentapeptide and the O-isopentenyl-D-tyrosine derivatives. Finally, the cyclization was achieved and the yield rate of Paecilodepsipeptide A was 72%. The structures of the synthesized product were identified by 1H NMR and 13C NMR spectra, which is identical to the natural product.
语种	中文
出版者	Beijing Institute of Technology
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/113748]
专题	生命科学与工程学院外国语学院党委组织部（党校、帮扶办）
作者单位	1.School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, Gansu 730050, China; 2.Lanzhou Jinchuan New Materials Co., Ltd., Lanzhou, Gansu 730000, China; 3.School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, China
推荐引用方式 GB/T 7714	Yang, Ming-Jun,Li, Juan,Wang, Yong-Gang,et al. Total synthesis of the active cyclodepsipeptides Paecilodepsipeptide A[J]. Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology,2013,33(7):765-770.
APA	Yang, Ming-Jun.,Li, Juan.,Wang, Yong-Gang.,Wu, Jing.,Zhang, Fei.,...&Zhang, Ying-Mei.(2013).Total synthesis of the active cyclodepsipeptides Paecilodepsipeptide A.Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology,33(7),765-770.
MLA	Yang, Ming-Jun,et al."Total synthesis of the active cyclodepsipeptides Paecilodepsipeptide A".Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology 33.7(2013):765-770.