Kinetics of base catalyzed racemization of ibuprofen enantiomers

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	Kinetics of base catalyzed racemization of ibuprofen enantiomers
	Xie, YC; Liu, HZ; Chen, JY
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2000-02-25
卷号	196 期号:1 页码:21-26
关键词	ibuprofen enantiomer resolution racemization kinetics base catalysis
ISSN号	0378-5173
其他题名	Int. J. Pharm.
中文摘要	The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved.
英文摘要	The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	RACEMIC IBUPROFEN ; ESTERIFICATION ; SOLVENT ; LIPASE ; DRUGS ; ENOL
收录类别	SCI
原文出处	://WOS:000085614600003
语种	英语
WOS记录号	WOS:000085614600003
公开日期	2013-11-15
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/5975]
专题	过程工程研究所_研究所（批量导入）
作者单位	Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Xie, YC,Liu, HZ,Chen, JY. Kinetics of base catalyzed racemization of ibuprofen enantiomers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2000,196(1):21-26.
APA	Xie, YC,Liu, HZ,&Chen, JY.(2000).Kinetics of base catalyzed racemization of ibuprofen enantiomers.INTERNATIONAL JOURNAL OF PHARMACEUTICS,196(1),21-26.
MLA	Xie, YC,et al."Kinetics of base catalyzed racemization of ibuprofen enantiomers".INTERNATIONAL JOURNAL OF PHARMACEUTICS 196.1(2000):21-26.