A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation

CORC > 过程工程研究所 > 中国科学院过程工程研究所 > 生化工程国家重点实验室

	A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation
	Ji, Qiu Xia 1; Zhao, Qing Sheng 2,3; Deng, Jing 1; Lue, Rui 4
刊名	JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
	2010-08-01
卷号	21 期号:8 页码:2435-2442
关键词	SINGLE-SPECIES BIOFILM IN-VITRO QUATERNIZED CHITOSAN ADULT PERIODONTITIS CONTROLLED-RELEASE DELIVERY SYSTEM TRIAL MINOCYCLINE GEL GLUCONATE
ISSN号	0957-4530
通讯作者	Ji, QX
英文摘要	The aim of this paper was to evaluate the application potential of CS-HTCC/GP-0.1%Chx thermosensitive hydrogel which was synthesized using chitosan (CS), quaternized CS, and alpha,beta-glycerophosphate (alpha,beta-GP) loading with 0.1% chlorhexidine (Chx) (w/v) for periodontal treatment. An aqueous solution of CS-HTCC/GP-0.1%Chx was transformed into hydrogel at 6 min when the temperature was increased to 37A degrees C. The scan electron microscopy (SEM) image of the gel was a porous, loose and crosslinked network. In vitro, Chx released over 18 h from the CS-HTCC/GP thermosensitive hydrogel in artificial saliva pH 6.8. Release rate could be controlled through adjustment of alpha,beta-GP or Chx concentration. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel exhibited excellent inhibitory activity against primary periodontal pathogens. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel had no acute toxicity; the maximum tolerated dose in rats was 400 mg/ml. All results indicated that CS-HTCC/GP-0.1%Chx thermosensitive hydrogel is a strong candidate as a local drug delivery system for periodontal treatment.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	SINGLE-SPECIES BIOFILM ; IN-VITRO ; QUATERNIZED CHITOSAN ; ADULT PERIODONTITIS ; CONTROLLED-RELEASE ; DELIVERY SYSTEM ; TRIAL ; MINOCYCLINE ; GEL ; GLUCONATE
收录类别	SCI ; ISTP
语种	英语
WOS记录号	WOS:000280814800023
公开日期	2013-11-15
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/6109]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Qingdao Univ, Dept Stomatol, Affiliated Hosp, Coll Med, Qingdao 266001, Shandong, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China 4.Qingdao Univ, Lab Med Microbiol, Coll Med, Qingdao 266001, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Ji, Qiu Xia,Zhao, Qing Sheng,Deng, Jing,et al. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2010,21(8):2435-2442.
APA	Ji, Qiu Xia,Zhao, Qing Sheng,Deng, Jing,&Lue, Rui.(2010).A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,21(8),2435-2442.
MLA	Ji, Qiu Xia,et al."A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 21.8(2010):2435-2442.