Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

doi:10.1002/gch2.201900042

CORC > 兰州理工大学 > 兰州理工大学 > 石油化工学院

	Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance
	Nurkesh, Ayan A.4; Sun, Qinglei 5; Fan, Haiyan 4; Dukenbayev, Kanat 1; Tsoy, Andrey 2; Altaikyzy, Akerke 4; Wang, Kunjie 3; Xie, Yingqiu 4
刊名	GLOBAL CHALLENGES
	2019-11-01
卷号	3 期号:11
关键词	bacteria drug resistance carbon nanodots nanobiology nanozymes pH Pim-1
DOI	10.1002/gch2.201900042
英文摘要	Carbon nanodots (C-dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C-dots can enhance targeted cancer therapy. However, in-depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit-derived C-dots, exhibits significant DNA damage; Annexin V/7-AAD-mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C-dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit-derived C-dots are observed inhibiting the horseradish peroxidase. Moreover, the C-dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim-1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C-dots, derived from the date-pit, as an efficient, low-cost, and green nanomaterial are reveled for cancer therapy and anti-infection.
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000483842900001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/155328]
专题	石油化工学院
作者单位	1.Nazarbayev Univ, Sch Engn, Nur Sultan 010000, Kazakhstan; 2.Nazarbayev Univ, Natl Lab Astana, Nur Sultan 010000, Kazakhstan; 3.Lanzhou Univ Technol, Coll Petrochem Technol, Lanzhou 730050, Gansu, Peoples R China 4.Nazarbayev Univ, Sch Sci & Humanities, Nur Sultan 010000, Kazakhstan; 5.Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Shandong, Peoples R China;
推荐引用方式 GB/T 7714	Nurkesh, Ayan A.,Sun, Qinglei,Fan, Haiyan,et al. Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance[J]. GLOBAL CHALLENGES,2019,3(11).
APA	Nurkesh, Ayan A..,Sun, Qinglei.,Fan, Haiyan.,Dukenbayev, Kanat.,Tsoy, Andrey.,...&Xie, Yingqiu.(2019).Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance.GLOBAL CHALLENGES,3(11).
MLA	Nurkesh, Ayan A.,et al."Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance".GLOBAL CHALLENGES 3.11(2019).