Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound | |
Yang, YS; Zhang, YP; Yang, AM; Lu, RH; Shi, YP; Shi, GF | |
刊名 | CHINESE JOURNAL OF CHEMISTRY
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2005-06 | |
卷号 | 23期号:6页码:775-780 |
关键词 | veronicafolin beta-cyclodextrin inclusion complex hydroxypropyl-beta-cyclodextrin improvement of solubility |
ISSN号 | 1001-604X |
英文摘要 | Inclusion complexation between veronicafolin, 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone, and beta-cyclodextrin (beta-CD) was investigated by using H-1 NMR, IR, X-ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid slate. The elemental analysis showed that the complex (1 : 1) of flavonol-beta-CD center dot 20H(2)O with C 39.58% and H 5.75% has been formed. The phase solubility profile of the favonol by UV-Vis in solution in the presence of hydroxypfropyl-beta-cyclodextrin (HP-beta-CD) was classified as A(L)-type, indicating the formation of I :: I inclusion complex. And the calibration equation y = 24148x+ 0.0075 (r= 0.9999) and phase-solubility diagram y = 0.4738x-2.0X10(-7) 10(-7\) (r=0.9490) were obtained. Stability constant K, was calculated from the phase solubility diagram (K-s=4.5 X 10(6)). Solubility of the veronicafolin was enhanced in the presence of HP-beta-CD. |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS记录号 | WOS:000229408100024 |
状态 | 已发表 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.223/handle/2XXMBERH/35778] ![]() |
专题 | 石油化工学院 生命科学与工程学院 |
通讯作者 | Yang, YS |
作者单位 | 1.Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou 730050, Gansu, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, YS,Zhang, YP,Yang, AM,et al. Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound[J]. CHINESE JOURNAL OF CHEMISTRY,2005,23(6):775-780. |
APA | Yang, YS,Zhang, YP,Yang, AM,Lu, RH,Shi, YP,&Shi, GF.(2005).Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound.CHINESE JOURNAL OF CHEMISTRY,23(6),775-780. |
MLA | Yang, YS,et al."Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound".CHINESE JOURNAL OF CHEMISTRY 23.6(2005):775-780. |
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