A Simple and Rapid CZE Determination of Tiapride Hydrochloride and Related Impurities in Pharmaceutical Formulations

doi:10.1365/s10337-009-1140-x

CORC > 兰州理工大学 > 兰州理工大学 > 石油化工学院

	A Simple and Rapid CZE Determination of Tiapride Hydrochloride and Related Impurities in Pharmaceutical Formulations
	Wang, Yuchun 1,3; Zhou, Lei 1,2; Hui, Yang 1,2; Chen, Xingguo 1,2
刊名	CHROMATOGRAPHIA
	2009-07
卷号	70 期号:1-2 页码:293-297
关键词	Capillary zone electrophoresis Pharmaceutical study Validation Tiapride
ISSN号	0009-5893
DOI	10.1365/s10337-009-1140-x
英文摘要	A simple, fast, inexpensive capillary zone electrophoresis method for the separation and determination of tiapride hydrochloride and its two related impurities in pharmaceutical formulations has been developed and validated. The successful separation of these compounds was achieved in less than 3 min using a fused silica capillary and photodiode array detector at 218 nm. The best conditions were obtained using a 10 mM sodium tetraborate (pH 8.0) as the running buffer. The linear responses covered the ranges from 1.0 to 100 mu g mL(-1) (R = 0.9989) for tiapride hydrochloride. The detection (LOD) and quantitation limits (LOQ) for tiapride hydrochloride were 2.7 and 9.0 mu g mL(-1), respectively. The intra- and inter-day relative standard deviations for migration times and peak areas were less than 0.47 and 5.7%, respectively. The method was validated for the determination of tiapride hydrochloride in commercial tablets.
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000268055600042
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/35373]
专题	石油化工学院
通讯作者	Wang, Yuchun
作者单位	1.Lanzhou Univ, Natl Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Dept Chem, Lanzhou 730000, Peoples R China 3.Lanzhou Univ Technol, Coll Petrochem Technol, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yuchun,Zhou, Lei,Hui, Yang,et al. A Simple and Rapid CZE Determination of Tiapride Hydrochloride and Related Impurities in Pharmaceutical Formulations[J]. CHROMATOGRAPHIA,2009,70(1-2):293-297.
APA	Wang, Yuchun,Zhou, Lei,Hui, Yang,&Chen, Xingguo.(2009).A Simple and Rapid CZE Determination of Tiapride Hydrochloride and Related Impurities in Pharmaceutical Formulations.CHROMATOGRAPHIA,70(1-2),293-297.
MLA	Wang, Yuchun,et al."A Simple and Rapid CZE Determination of Tiapride Hydrochloride and Related Impurities in Pharmaceutical Formulations".CHROMATOGRAPHIA 70.1-2(2009):293-297.