The research of the generalized tonic-clonic seizure epilepsy by resting state fMRI

	The research of the generalized tonic-clonic seizure epilepsy by resting state fMRI
	Ke, Ming 2; Duan, Xiaoxin 2; Zhang, Fan 2; Yang, Xiaoping 1
	2015
关键词	epilepsy fMRI Pearson correlation network attributes synchronicity
卷号	126
页码	1673-1678
英文摘要	In this study, we investigated the human brain functional network of patients with generalized tonic and clonic seizure (GTCS) epilepsy by using the resting-state functional magnetic resonance imaging (fMRI) and complex network theory. Adjacency matrices of the networks of GTCS group and normal control group were constructed by the method of Pearson correlation coefficient. A intra-group analysis was performed to get a statistical map of each group. And it was contrasted the attributes of brain network from two aspects of the "small world" property and network efficiency. Furthermore, a inter-group analysis was conducted to investigate differences between GTCS group and normal control group. Our results showed the "small world" property and network efficiency of GTCS group were decreased compared to the controls. In addition, the patients exhibited increased correlation coefficient mainly concentrated in the thalamus and the lentiform nucleus, while the decreased correlation coefficient was mainly distributed in the precuneus and frontal lobe, the inferior frontal gyrus, the inferior parietal gyrus, the superior parietal gyrus. The result indicated that information transmission ability of brain function network in patients with GTCS is impaired. And it also suggested that the method of Pearson correlation coefficient can detect synchronization change of blood-oxygen levels in the brain so that achieved the goal of positioning detection of epileptic activity.
会议录	PROCEEDINGS OF THE FIRST INTERNATIONAL CONFERENCE ON INFORMATION SCIENCES, MACHINERY, MATERIALS AND ENERGY (ICISMME 2015)
会议录出版者	ATLANTIS PRESS
会议录出版地	29 AVENUE LAVMIERE, PARIS, 75019, FRANCE
语种	英语
WOS研究方向	Computer Science ; Energy & Fuels ; Materials Science
WOS记录号	WOS:000359818900345
内容类型	会议论文
源URL	[http://119.78.100.223/handle/2XXMBERH/38427]
专题	计算机与通信学院
通讯作者	Ke, Ming
作者单位	1.Lanzhou Mil Command, Lanzhou Gen Hosp, Dept Imaging Diag, Lanzhou 730050, Gansu, Peoples R China 2.Lanzhou Univ Technol, Coll Comp & Commun, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Ke, Ming,Duan, Xiaoxin,Zhang, Fan,et al. The research of the generalized tonic-clonic seizure epilepsy by resting state fMRI[C]. 见:.