Evaluating the Cytotoxicity of Ti(3)C(2 )MXene to Neural Stem Cells

doi:10.1021/acs.chemrestox.0c00232

	Evaluating the Cytotoxicity of Ti(3)C(2 )MXene to Neural Stem Cells
	Wu, Wei 1,2; Ge, Hongfei 1; Zhang, Long 3; Lei, Xuejiao 1; Yang, Yang 1; Fu, Yan 4; Feng, Hua 1
刊名	CHEMICAL RESEARCH IN TOXICOLOGY
	2020-12-21
卷号	33 期号:12 页码:2953-2962
ISSN号	0893-228X
DOI	10.1021/acs.chemrestox.0c00232
英文摘要	MXenes have attracted extensive attention due to their unique physicochemical properties. Especially, the flexibility and good conductivity endow MXenes with a great application prospect in the neural interfaces. However, the cytotoxicity of MXenes to nervous system remains unclear. In this study, we evaluated the cytotoxicity of Ti3C2 (the most studied MXenes) using primary neural stem cells (NSCs) and NSCs-derived differentiated cells in terms of apoptosis, viability, cellular uptake, cell membrane integrity, and global gene expression profiles. We found that 12.5 mu g/mL Ti3C2 had no observable adverse effect on NSCs and NSCs-derived differentiated cells. However, 25 mu g/mL Ti3C2 induced significant cytotoxicity and were internalized into the NSCs cells with compromised cell membrane. Furthermore, in the NSCs exposure to 25 mu g/mL Ti3C2, we identified 198 differently expressed genes (DEGs), which were mainly associated with the extracellular region. Besides, the DEGs were involved in inflammatory, defense, stress, and stimulus response. This work will improve our understanding of biocompatibility of MXenes in the nervous system and promote the biomedical application of MXenes.
WOS研究方向	Pharmacology & Pharmacy ; Chemistry ; Toxicology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000602573000007
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/155029]
专题	材料科学与工程学院
作者单位	1.Third Mil Med Univ, Army Med Univ, Dept Neurosurg, Southwest Hosp, Chongqing 400038, Peoples R China; 2.Third Mil Med Univ, Army Med Univ, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China; 3.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Peoples R China; 4.Gen Hosp Western Theater Command, Chengdu 610000, Peoples R China
推荐引用方式 GB/T 7714	Wu, Wei,Ge, Hongfei,Zhang, Long,et al. Evaluating the Cytotoxicity of Ti(3)C(2 )MXene to Neural Stem Cells[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2020,33(12):2953-2962.
APA	Wu, Wei.,Ge, Hongfei.,Zhang, Long.,Lei, Xuejiao.,Yang, Yang.,...&Feng, Hua.(2020).Evaluating the Cytotoxicity of Ti(3)C(2 )MXene to Neural Stem Cells.CHEMICAL RESEARCH IN TOXICOLOGY,33(12),2953-2962.
MLA	Wu, Wei,et al."Evaluating the Cytotoxicity of Ti(3)C(2 )MXene to Neural Stem Cells".CHEMICAL RESEARCH IN TOXICOLOGY 33.12(2020):2953-2962.