Preparation of Poly (N-vinyl Caprolactam-co-N, N-Dimethylacrylamide) Smart Hydrogel by Frontal Polymerization

doi:10.11896/cldb.20050243

	Preparation of Poly (N-vinyl Caprolactam-co-N, N-Dimethylacrylamide) Smart Hydrogel by Frontal Polymerization
	Zhu, Jinlong 1,2; Zheng, Jucheng 2; Zhang, Dingjun 1
刊名	Cailiao Daobao/Materials Reports
	2021-08-25
卷号	35 期号:16 页码:16149-16154
关键词	Acrylic monomers Controlled drug delivery Copolymerization Molar ratio Swelling Targeted drug delivery Temperature Wave propagation Cross linking agents Dimethyl acrylamide Frontal polymerization Intelligent hydrogel Molar ratio N-dimethacrylamide Phase transition temperatures Poly N Poly N-vinyl caprolactam Temperature sensitivity
ISSN号	1005023X
DOI	10.11896/cldb.20050243
英文摘要	In this paper, the poly (N-vinyl caprolactam-co-N, N-dimethylacrylamide) intelligent hydrogel was prepared by frontal polymerization. Accor-ding to two kinds of monomer, N-vinyl caprolactam (N-VCL) and N, N-dimethylacrylamide (DMAA), the effects of monomer molar ratio, crosslinking agent and initiator on the frontal polymerization parameters and the properties of the copolymerization hydrogel were studied. Using aspirin as a model drug, the effects of copolymer hydrogel on aspirin loading and releasing were evaluated. The results show that the copolymers have temperature sensitivity, the phase transition temperature is between 25-40, and the sensitivity of the gel to the sensitivity of the temperature stimulation is more obvious after the addition of the monomer. With the increase of the content of the monomer DMAA, the wave temperature and wave velocity increase, the swelling rate of the greenhouse increases. When the molar ratio of the two monomers is n(N-VCL):n(DMAA)=5:5, the temperature sensitivity of the hydrogel is the best. With the increase of the amount of crosslinking agent, the swelling capacity and temperature sensitivity of the copolymer gel decreased. The phase transition temperature increases with the increase of initiator dosage. As the ratio of DMAA monomer increased, the gel drug loading increased at 25 and 37, but as far as drug release effect was concerned, gel release efficiency and total drug release rate were higher at 37. © 2021, Materials Review Magazine. All right reserved.
语种	中文
出版者	Cailiao Daobaoshe/ Materials Review
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/150920]
专题	材料科学与工程学院
作者单位	1.School of Material Science and Engineering, Lanzhou University of Technology, Lanzhou; 730050, China; 2.Lanzhou Petrochemical Research Center, PetroChina, Lanzhou; 730060, China
推荐引用方式 GB/T 7714	Zhu, Jinlong,Zheng, Jucheng,Zhang, Dingjun. Preparation of Poly (N-vinyl Caprolactam-co-N, N-Dimethylacrylamide) Smart Hydrogel by Frontal Polymerization[J]. Cailiao Daobao/Materials Reports,2021,35(16):16149-16154.
APA	Zhu, Jinlong,Zheng, Jucheng,&Zhang, Dingjun.(2021).Preparation of Poly (N-vinyl Caprolactam-co-N, N-Dimethylacrylamide) Smart Hydrogel by Frontal Polymerization.Cailiao Daobao/Materials Reports,35(16),16149-16154.
MLA	Zhu, Jinlong,et al."Preparation of Poly (N-vinyl Caprolactam-co-N, N-Dimethylacrylamide) Smart Hydrogel by Frontal Polymerization".Cailiao Daobao/Materials Reports 35.16(2021):16149-16154.