Polygonatum polysaccharide modified montmorillonite/chitosan/glycerophosphate composite hydrogel for bone tissue engineering

doi:10.1080/00914037.2021.1960336

	Polygonatum polysaccharide modified montmorillonite/chitosan/glycerophosphate composite hydrogel for bone tissue engineering
	Zhao, Xiaoliang 1; Li, Pingping 1; Zhu, Jianning 4; Xia, Yunya 3; Ma, Jianzhong 1; Pu, Xiuying 1; Wang, Yonggang 1; Leng, Feifan 1; Wang, Yanling 1; Yang, Shuhong 1
刊名	INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
	2021-08
关键词	Bone tissue engineering intelligent composite hydrogel polygonatum polysaccharide thermo-responsive
ISSN号	0091-4037
DOI	10.1080/00914037.2021.1960336
英文摘要	The stiffness and gelation temperature of thermo-responsive chitosan (CS), glycerophosphate (GP) hydrogel is not enough for differentiation of BMSCs and injecting use in bone defect repair. To improve these weaknesses, a kind of injectable hydrogel (PMCG) was prepared with Chitosan (CS), glycerophosphate (GP), polygonatum polysaccharide modified montmorillonite (PMMT). The gelation temperature of CS/GP (CG) hydrogel was 42 degrees C, the maximum mechanical strength was 1061 Pa. with the amount of PMMT increased, the gelation temperature decreased to 28 degrees C, and the maximum stiffness increased to 6789 Pa. At the same time, with the addition of PMMT, the swelling property of hydrogel was improved. The cytocompatibility of PMCG decreased than CG which maybe result from the poor cytocompatibility of montmorillonite, but it was improved with increasing amount of PMMT, which indicated the cell proliferation promoting effect coming from polygonatum polysaccharide. The SEM-EDX exhibited that these hydrogels possessed excellent morphological characteristics and could promote mineralization in simulated body fluid (SBF) solution, PMCG-2 Ca/P has a Ca/P ratio of 1.63 +/- 0.04, which is similar to the ratio of human bone mineral (Ca/P ratio of 1.55-1.75). The cell viability confirmed the application availability of the hydrogel. In light of the effect on osteoblasts maturation promoting effect and decrease of osteoclast of polygonatum polysaccharide. We come to the conclusion that it is an effective strategy to improve the mechanic strength and gelation temperature, and keep the osteogenesis promoting effect at the same time.
WOS研究方向	Materials Science ; Polymer Science
语种	英语
出版者	TAYLOR & FRANCIS AS
WOS记录号	WOS:000688032600001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/148873]
专题	生命科学与工程学院材料科学与工程学院
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Room 306,2 Langongping South St, Lanzhou 730050, Gansu, Peoples R China; 2.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 3.China Natl Intellectual Property Adm, Beijing 102206, Peoples R China; 4.Gansu Drug Adm Review & Certificat Ctr, Lanzhou 730050, Gansu, Peoples R China;
推荐引用方式 GB/T 7714	Zhao, Xiaoliang,Li, Pingping,Zhu, Jianning,et al. Polygonatum polysaccharide modified montmorillonite/chitosan/glycerophosphate composite hydrogel for bone tissue engineering[J]. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,2021.
APA	Zhao, Xiaoliang.,Li, Pingping.,Zhu, Jianning.,Xia, Yunya.,Ma, Jianzhong.,...&Zhang, Weijie.(2021).Polygonatum polysaccharide modified montmorillonite/chitosan/glycerophosphate composite hydrogel for bone tissue engineering.INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS.
MLA	Zhao, Xiaoliang,et al."Polygonatum polysaccharide modified montmorillonite/chitosan/glycerophosphate composite hydrogel for bone tissue engineering".INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2021).