Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility

doi:10.1016/j.actbio.2013.07.010

	Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility
	Wang, L. R.1; Qin, H.1; Nie, S. Q.2; Sun, S. D.1; Ran, F.3; Zhao, C. S.1,2
刊名	ACTA BIOMATERIALIA
	2013-11
卷号	9 期号:11 页码:8851-8863
关键词	Heparin-like poly(ethersulfone) Polycondensation Hydrophilicity group Blood compatibility
ISSN号	1742-7061
DOI	10.1016/j.actbio.2013.07.010
英文摘要	In this study, heparin-like poly(ethersulfone) (HLPES) was synthesized by a combination of polycondensation and post-carboxylation methods, and was characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance hydrogen spectrum and gel permeation chromatography. Owing to the similar backbone structure, the synthesized HLPES could be directly blended with pristine PES at any ratios to prepare PES/HLPES membranes. After the introduction of HLPES, the microscopic structure of the modified PES membranes was changed, while the hydrophilicity was significantly enhanced. Bovine serum albumin and bovine serum fibrinogen adsorption, activated partial thromboplastin time, thromb time and platelet adhesion for the modified PES membranes were investigated. The results indicated that the blood compatibility of the PES/HLPES membranes was significantly improved compared with that of pristine PES membrane. For the PES/HLPES membranes, obvious decreases in platelet activation on PF-4 level, in complement activation on C3a and C5a levels, and in leukocytes activation on CD11b levels were observed compared with those for the pristine PES membrane. The improved blood compatibility of the PES/HLPES membrane might due to the existence of the hydrophilic groups (-SO3Na, -COONa). Furthermore, the modified PES membranes showed good cytocompatibility. Hepatocytes cultured on the PES/HLPES membranes presented improved growth in terms of SEM observation, MTT assay and confocal laser scanning microscope observation compared with those on the pristine PES membrane. These results indicate that the PES/HLPES membranes present great potential in blood-contact fields such as hemodialysis and bio-artificial liver supports. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
资助项目	State Education Ministry of China (Doctoral Program for High Education)[20100181110031]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000326902500008
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34609]
专题	材料科学与工程学院省部共建有色金属先进加工与再利用国家重点实验室
通讯作者	Zhao, C. S.
作者单位	1.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China 2.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China 3.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Wang, L. R.,Qin, H.,Nie, S. Q.,et al. Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility[J]. ACTA BIOMATERIALIA,2013,9(11):8851-8863.
APA	Wang, L. R.,Qin, H.,Nie, S. Q.,Sun, S. D.,Ran, F.,&Zhao, C. S..(2013).Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility.ACTA BIOMATERIALIA,9(11),8851-8863.
MLA	Wang, L. R.,et al."Direct synthesis of heparin-like poly(ether sulfone) polymer and its blood compatibility".ACTA BIOMATERIALIA 9.11(2013):8851-8863.