Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing

doi:10.1002/btm2.10345

CORC > 兰州理工大学 > 兰州理工大学

	Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing
	Xu, Hongtao 1,2,3; Zhu, Yanlun 4,5; Xu, Jiankun 1,2; Tong, Wenxue 1,2; Hu, Shiwen 1,2,6; Chen, Yi-Fan 7,8,9,10; Deng, Shuai 4,5; Yao, Hao 1,2; Li, Jie 11; Lee, Chien-Wei 12
刊名	BIOENGINEERING & TRANSLATIONAL MEDICINE
	2022-06-01
关键词	bioactive glass hydrogel immunomodulatory injectable tendon healing
DOI	10.1002/btm2.10345
英文摘要	Tendon healing is a complex process involving inflammation, proliferation, and remodeling, eventually achieving a state of hypocellularity and hypovascularity. Currently, few treatments can satisfactorily restore the structure and function of native tendon. Bioactive glass (BG) has been shown to possess immunomodulatory and angiogenic properties. In this study, we investigated whether an injectable hydrogel fabricated of BG and sodium alginate (SA) could be applied to enhance tenogenesis following suture repair of injured tendon. We demonstrated that BG/SA hydrogel significantly accelerated tenogenesis without inducing heterotopic ossification based on histological analysis. The therapeutic effect could attribute to increased angiogenesis and M1 to M2 phenotypic switch of macrophages within 7 days post-surgery. Morphological characterization demonstrated that BG/SA hydrogel partially reverted the pathological changes of Achilles tendon, including increased length and cross-sectional area (CSA). Finally, biomechanical test showed that BG/SA hydrogel significantly improved ultimate load, failure stress, and tensile modulus of the repaired tendon. In conclusion, administration of an injectable BG/SA hydrogel can be a novel and promising therapeutic approach to augment Achilles tendon healing in conjunction with surgical intervention.
WOS研究方向	Biotechnology & Applied Microbiology ; Engineering ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000805194900001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/158962]
专题	兰州理工大学
作者单位	1.Chinese Univ Hong Kong, Dept Orthoped & Traumatol, Musculoskeletal Res Lab, Hong Kong, Peoples R China; 2.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Innovat Orthopaed Biomat & Drug Translat Res Lab, Hong Kong, Peoples R China; 3.Nanjing Med Univ, Affiliated Hosp 1, Dept Orthoped, Nanjing, Peoples R China; 4.Chinese Univ Hong Kong, Fac Med, Inst Tissue Engn & Regenerat Med, Hong Kong, Peoples R China; 5.Chinese Univ Hong Kong, Key Lab Regenerat Med, Minist Educ China, Sch Biomed Sci,Fac Med, Hong Kong, Peoples R China; 6.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou, Peoples R China; 7.Taipei Med Univ, Coll Med Sci & Technol, PhD Program Translat Med, Taipei, Taiwan; 8.Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Translat Med, Taipei, Taiwan; 9.Taipei Med Univ, Coll Med Sci & Technol, Int PhD Program Translat Sci, Taipei, Taiwan; 10.Taipei Med Univ, Sch Pharm, Master Program Clin Genom & Prote, Taipei, Taiwan;
推荐引用方式 GB/T 7714	Xu, Hongtao,Zhu, Yanlun,Xu, Jiankun,et al. Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing[J]. BIOENGINEERING & TRANSLATIONAL MEDICINE,2022.
APA	Xu, Hongtao.,Zhu, Yanlun.,Xu, Jiankun.,Tong, Wenxue.,Hu, Shiwen.,...&Chan, Hon Fai.(2022).Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing.BIOENGINEERING & TRANSLATIONAL MEDICINE.
MLA	Xu, Hongtao,et al."Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing".BIOENGINEERING & TRANSLATIONAL MEDICINE (2022).