A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate

CORC > 过程工程研究所 > 中国科学院过程工程研究所 > 研究所（批量导入）

	A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate
	Wu, J ; Su, ZG ; Ma, GH
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2006-06-06
卷号	315 期号:1-2 页码:1-11
关键词	quaternized chitosan hydrogel injectable implant thermosensitivity pH-sensitivity controlled release
ISSN号	0378-5173
其他题名	Int. J. Pharm.
中文摘要	The quaternized chitosan was synthesized by the reaction of chitosan and glycidyltrimethylammonium chloride (GTMAC) and named as N-[(2-hydroxy-3-trimethyl ammonium) propyl] chitosan chloride (HTCC). A novel hydrogel system composed of HTCC/glycerophosphate (HTCC/GP) with thermo- and pH-sensitivity was synthesized and used as an intelligent drug carrier. The formulation was solution below or at room temperature, which allowed it injectable and to incorporate living cells, proteins, enzymes or other therapeutic drugs easily. Once the surrounding temperature was up to 37 degrees C the system was transformed to a non-flowing hydrogel, and the formed hydrogel can release the trapped drug as a function of pH values. The swelling behavior of the system and the release profiles of doxorubicin hydrochloride (DX) as a model drug at different pH values were investigated. At acidic condition the hydrogel dissolved and released drug quickly, while it absorbed water and released drug slowly at neutral or basic conditions. Hydrogel composed of chitosan hydrochloride and glycerophosphate (CS/GP) was also prepared to compare with HTCC/GP hydrogel. The HTCC/GP hydrogel in this study was transparent which made it suitable for some specific uses such as ocular drug formulation. (c) 2006 Elsevier B.V. All rights reserved.
英文摘要	The quaternized chitosan was synthesized by the reaction of chitosan and glycidyltrimethylammonium chloride (GTMAC) and named as N-[(2-hydroxy-3-trimethyl ammonium) propyl] chitosan chloride (HTCC). A novel hydrogel system composed of HTCC/glycerophosphate (HTCC/GP) with thermo- and pH-sensitivity was synthesized and used as an intelligent drug carrier. The formulation was solution below or at room temperature, which allowed it injectable and to incorporate living cells, proteins, enzymes or other therapeutic drugs easily. Once the surrounding temperature was up to 37 degrees C the system was transformed to a non-flowing hydrogel, and the formed hydrogel can release the trapped drug as a function of pH values. The swelling behavior of the system and the release profiles of doxorubicin hydrochloride (DX) as a model drug at different pH values were investigated. At acidic condition the hydrogel dissolved and released drug quickly, while it absorbed water and released drug slowly at neutral or basic conditions. Hydrogel composed of chitosan hydrochloride and glycerophosphate (CS/GP) was also prepared to compare with HTCC/GP hydrogel. The HTCC/GP hydrogel in this study was transparent which made it suitable for some specific uses such as ocular drug formulation. (c) 2006 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	CHITOSAN HYDROGELS ; BIOMEDICAL APPLICATIONS ; POLYMERIC MICELLES ; AQUEOUS-SOLUTIONS ; PROTEIN CARRIER ; COPOLYMERS ; DELIVERY ; WATER
收录类别	SCI
原文出处	://WOS:000238106100001
语种	英语
WOS记录号	WOS:000238106100001
公开日期	2013-10-24
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/4109]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, J,Su, ZG,Ma, GH. A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2006,315(1-2):1-11.
APA	Wu, J,Su, ZG,&Ma, GH.(2006).A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate.INTERNATIONAL JOURNAL OF PHARMACEUTICS,315(1-2),1-11.
MLA	Wu, J,et al."A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate".INTERNATIONAL JOURNAL OF PHARMACEUTICS 315.1-2(2006):1-11.