A pH-responsive gating membrane system with pumping effects for improved controlled release

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	A pH-responsive gating membrane system with pumping effects for improved controlled release
	Qu, J. B. ; Chu, L. Y. ; Yang, M. ; Xie, R. ; Hu, L. ; Chen, W. M.
刊名	Advanced Functional Materials
	2006
期号	14 页码:1865-1872
关键词	group-transfer polymerization shell hydrogel nanoparticles drug-delivery functional gates porous membranes pore-size core microspheres microcapsules microgels
其他题名	Adv. Funct. Mater.
中文摘要	In this study, we report on a novel composite membrane system for pH-responsive controlled release, which is composed of a porous membrane with linear grafted, positively pH-responsive polymeric gates acting as functional valves, and a crosslinked, negatively pH-responsive hydrogel inside the reservoir working as a functional pumping element. The proposed system features a large responsive release rate that goes effectively beyond the limit of concentration-driven diffusion due to the pumping effects of the negatively pH-responsive hydrogel inside the reservoir. The pH-responsive gating membranes were prepared by grafting poly(methacrylic acid) (PMAA) linear chains onto porous polyvinylidene fluoride (PVDF) membrane substrates using a plasma-graft pore-filling polymerization, and the crosslinked poly(N,N-dimethylaminoethyl methacrylate) (PDM) hydrogels were synthesized by free radical polymerization. The volume phase-transition characteristics of PMAA and PDM were opposite. The proposed system opens new doors for pH-responsive "smart" or "intelligent" controlled-release systems, which are highly attractive for drug-delivery systems, chemical carriers, sensors, and so on.
原文出处	://WOS:000241014700011
语种	英语
公开日期	2013-10-24
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/4037]
专题	过程工程研究所_研究所（批量导入）
推荐引用方式 GB/T 7714	Qu, J. B.,Chu, L. Y.,Yang, M.,et al. A pH-responsive gating membrane system with pumping effects for improved controlled release[J]. Advanced Functional Materials,2006(14):1865-1872.
APA	Qu, J. B.,Chu, L. Y.,Yang, M.,Xie, R.,Hu, L.,&Chen, W. M..(2006).A pH-responsive gating membrane system with pumping effects for improved controlled release.Advanced Functional Materials(14),1865-1872.
MLA	Qu, J. B.,et al."A pH-responsive gating membrane system with pumping effects for improved controlled release".Advanced Functional Materials .14(2006):1865-1872.