Dual responsive copolymer micelles for drug controlled release

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	Dual responsive copolymer micelles for drug controlled release
	Yang, Liangrong; Guo, Chen; Jia, Lianwei; Liang, Xiangfeng; Liu, Chunzhao; Liu, Huizhou
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2010-10-01
卷号	350 期号:1 页码:22-29
关键词	Temperature responsive pH responsive Polymeric micelles Drug controlled release
ISSN号	0021-9797
通讯作者	Guo, C
英文摘要	pH- and temperature-responsive polymeric drug carriers based on Chitosan oligosaccharide (CSO)-g-Pluronic copolymers were successfully synthesized for Doxorubicin (DOX) controlled release. The critical aggregation concentration of CSO-g-Pluronic is 0.035 mg/mL at 25 degrees C. The CSO-g-Pluronic and DOX-loaded CSO-g-Pluronic micelles have an average hydrodynamic diameter of 23.3 nm and 43.6 nm respectively at 30 degrees C and pH 7.0 with narrow size distribution. The temperature or pH responsive behavior of the micelles was characterized by dynamic light scattering, fluorescence spectroscopy, and zeta Potential Analysis. The temperature-dependent micellar transformation was induced by dehydration of Pluronic segments at higher temperature. The pH responsive volume increase was traced to the electrostatic repulsion between CSO segments from protonation of amino groups under acidic conditions. Consequently, the DOX release time was prolonged by CSO-g-Pluronic micelles at body temperature of 37 degrees C, and the DOX release was accelerated at mild acidic conditions (i.e. the pH environment around tumor tissues). The temperature- and pH-responsive properties of CSO-g-Pluronic copolymer have provided promising potentials for biomedical and biotechnological applications. (C) 2010 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Physical
研究领域[WOS]	Chemistry
关键词[WOS]	PLURONIC((R)) BLOCK-COPOLYMERS ; AQUEOUS-SOLUTIONS ; AGGREGATION BEHAVIOR ; TRIBLOCK COPOLYMERS ; PEPTIDE DELIVERY ; GRAFTED CHITOSAN ; OXIDE) ; NANOPARTICLES ; TEMPERATURE ; MICELLIZATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000281048300005
公开日期	2013-11-12
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/5703]
专题	过程工程研究所_湿法冶金清洁生产技术国家工程实验室
作者单位	Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yang, Liangrong,Guo, Chen,Jia, Lianwei,et al. Dual responsive copolymer micelles for drug controlled release[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2010,350(1):22-29.
APA	Yang, Liangrong,Guo, Chen,Jia, Lianwei,Liang, Xiangfeng,Liu, Chunzhao,&Liu, Huizhou.(2010).Dual responsive copolymer micelles for drug controlled release.JOURNAL OF COLLOID AND INTERFACE SCIENCE,350(1),22-29.
MLA	Yang, Liangrong,et al."Dual responsive copolymer micelles for drug controlled release".JOURNAL OF COLLOID AND INTERFACE SCIENCE 350.1(2010):22-29.