Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids

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	Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids
	Liu, Yanjuan 1,2,3; Liu, Junxi 1,2; Di, Duolong 1,2; Li, Min 4; Fen, Yan 5
刊名	CURRENT TOPICS IN MEDICINAL CHEMISTRY
	2013-09
卷号	13 期号:17 页码:2116-2126
关键词	Natural product Aporphinoid alkaloids Chemical structure Anticancer activity Apoptosis SARs
ISSN号	1568-0266
英文摘要	Aporphinoid alkaloids, which encompass a large number of complicated structures, are an important group of natural products. The anticancer activity of aporphinoid alkaloids has become a hot pharmaceutical research area in recent years. Recent studies on the anticancer activity of these compounds are reviewed. The structure activity relationships (SARs) and anticancer mechanisms of aporphinoid alkaloids, as well as simple aporphine, oxoaporphine, dehydroaporphine and dimeric aporphine, have been summarized. The presence of a 1,2-methylenedioxy group and methylation of nitrogen are key features to the cytotoxicity of aporphinoid alkaloids. Oxidation and dehydrogenation of C-7 could improve the anticancer activity. The contributions of chirality of hydrogen at C-6a and the substitution pattern of other positions about aporphinoid alkaloids for anticancer activity remain unknown. Induced cancer cells apoptosis, prevention of cell proliferation, DNA topoisomerase inhibition, reducing the drug-resistant cellular side population (SP) or cancer stem cells (CSCs) and inhibition of epidermal growth factor receptor (EGFR) tyrosine kinase seem to play important roles in the molecular mechanisms of anticancer activity about aporphinoid alkaloids.
资助项目	national natural sciences foundation of China[NSFC 20974116]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000324801300004
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34635]
专题	兰州理工大学石油化工学院生命科学与工程学院
通讯作者	Liu, Junxi
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Lanzhou Univ Technol, Coll Petrochem Engn, Lanzhou 730000, Peoples R China 5.Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yanjuan,Liu, Junxi,Di, Duolong,et al. Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2013,13(17):2116-2126.
APA	Liu, Yanjuan,Liu, Junxi,Di, Duolong,Li, Min,&Fen, Yan.(2013).Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids.CURRENT TOPICS IN MEDICINAL CHEMISTRY,13(17),2116-2126.
MLA	Liu, Yanjuan,et al."Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids".CURRENT TOPICS IN MEDICINAL CHEMISTRY 13.17(2013):2116-2126.