Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice

doi:10.3389/fimmu.2022.857242

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice
	Zhang, Yubing 3,4; Qin, Song 2,4; Song, Yipeng 1; Yuan, Jingyi 2,4; Hu, Shanliang 1; Chen, Min 3; Li, Lili 2,4
刊名	FRONTIERS IN IMMUNOLOGY
	2022-04-01
卷号	13 页码:12
关键词	alginate oligosaccharide cisplatin gut microbiota metabolomics FAHFAs Nrf2 oxidative stress inflammation
ISSN号	1664-3224
DOI	10.3389/fimmu.2022.857242
通讯作者	Li, Lili(llli@yic.ac.cn)
英文摘要	Alginate oligosaccharide is the depolymerized product of alginate, a natural extract of brown algae, which is associated with beneficial health effects. Here, we aimed to investigate the mechanism via which alginate oligosaccharides improve kidney oxidative damage and liver inflammation induced by cisplatin chemotherapy via the gut microbiota. C57BL/6J mice were treated with cisplatin were administered alginate oligosaccharide via gavage for 3 weeks. Compared to that observed in the cisplatin chemotherapy group without intragastric administration of alginate oligosaccharide, liver inflammation improved in the alginate oligosaccharide group, indicated by reduction in lipopolysaccharide and interleukin-1 beta (IL-1 beta) levels. This was accompanied by improvement in the oxidative stress of mice kidneys, indicated by the increase in the levels of superoxide dismutase (SOD), catalase (CAT) and nuclear NF-E2-related factor 2 (Nrf2) in renal tissue, and reduction in the levels of malondialdehyde (MDA) in renal tissue and serum creatinine (Cr) to the levels of the normal control group. Alginate oligosaccharide intervention increased the concentration of fatty acid esters of hydroxy fatty acids (FAHFAs). Alginate oligosaccharide regulated the composition of the intestinal microbial community and promoted Lactobacillus stains, such as Lactobacillus johnsonii and Lactobacillus reuteri. Spearman analysis showed that 5 members of FAHFAs concentrations were positively correlated with Lactobacillus johnsonii and Lactobacillus reuteri abundance. We observed that alginate oligosaccharide increased FAHFAs producing-related bacterial abundance and FAHFAs levels, enhanced the levels of SOD and CAT in kidney tissue, and reduced the levels of MDA via activating Nrf2, thereby ameliorating the renal redox injury caused by cisplatin chemotherapy.
WOS关键词	MICROBIOTA ; INJURY ; RESCUE
WOS研究方向	Immunology
语种	英语
WOS记录号	WOS:000787926600001
资助机构	Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Program of Yantai
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31249]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Li, Lili
作者单位	1.Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 3.Yantai Univ, Coll Life Sci, Yantai, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yubing,Qin, Song,Song, Yipeng,et al. Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice[J]. FRONTIERS IN IMMUNOLOGY,2022,13:12.
APA	Zhang, Yubing.,Qin, Song.,Song, Yipeng.,Yuan, Jingyi.,Hu, Shanliang.,...&Li, Lili.(2022).Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice.FRONTIERS IN IMMUNOLOGY,13,12.
MLA	Zhang, Yubing,et al."Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice".FRONTIERS IN IMMUNOLOGY 13(2022):12.