Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice

doi:10.1016/j.jff.2022.105119

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	Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice
	Deng, Zhenzhen 1,2,3,4; Wang, Jing 1,2,4; Wu, Ning 1,2,4; Geng, Lihua 1,2,4; Zhang, Quanbin 1,2,3,4; Yue, Yang 1,2,4
刊名	JOURNAL OF FUNCTIONAL FOODS
	2022-07-01
卷号	94 页码:9
关键词	Fucoxanthin Fucoidan Metabolic Syndrome AMPK Signaling Axis
ISSN号	1756-4646
DOI	10.1016/j.jff.2022.105119
通讯作者	Yue, Yang(yueyang@qdio.ac.cn)
英文摘要	Metabolic syndrome (MetS) is a pathological condition characterized by multiple metabolic abnormalities. With the global epidemic of obesity and diabetes, MetS needs more urgent treatments and interventions. Fucoxanthin (FX) and fucoidan are two important active components derived from brown algae, which have been recommended as adjunctive therapy for MetS. In this study, we found that FX and low molecular weight fucoidan fraction LF2 improved insulin resistance (IR) and enhanced insulin sensitivity in high fat diet (HFD)-induced MetS mice synergistically. LF2 and FX could ameliorate HFD-induced liver injury by reducing liver fat deposition, inflammatory response and oxidative stress. Adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling axis is a key target for LF2 and FX to improve MetS. FX and LF2 reduced adipogenesis and conversion through co-activation of AMPK and reduction of the expression of adipogenic differentiation factors. In addition, FX up-regulated the expression of uncoupling protein (UCP-1) and promoted the body's energy expenditure. However, LF2 did not significantly increase the anti-hyperlipidemic effect of FX. Collectively, this study elucidated the synergistic improvement of MetS by FX and LF2 from a molecular perspective. It also demonstrated the potential of fucoxanthin combined with fucoidan as an anti-MetS functional food.
WOS研究方向	Food Science & Technology ; Nutrition & Dietetics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000807851100001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/179686]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Yue, Yang
作者单位	1.Inst Oceanol, Chinese Acad Sci, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Tech, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Deng, Zhenzhen,Wang, Jing,Wu, Ning,et al. Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice[J]. JOURNAL OF FUNCTIONAL FOODS,2022,94:9.
APA	Deng, Zhenzhen,Wang, Jing,Wu, Ning,Geng, Lihua,Zhang, Quanbin,&Yue, Yang.(2022).Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice.JOURNAL OF FUNCTIONAL FOODS,94,9.
MLA	Deng, Zhenzhen,et al."Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice".JOURNAL OF FUNCTIONAL FOODS 94(2022):9.