Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model

doi:10.1007/s00253-022-12044-4

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model
	Yuan, Jingyi 3; Qin, Song 2,3; Hu, Shanliang 1; Liu, Zhengyi 2,3; Song, Yipeng 1; Li, Lili 2,3
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2022-07-02
页码	13
关键词	Cefixime Prebiotic blend Gut microbiota Metabolome
ISSN号	0175-7598
DOI	10.1007/s00253-022-12044-4
通讯作者	Li, Lili(llli@yic.ac.cn)
英文摘要	Recent studies have provided compelling evidence linking the composition of the gut microbiota, host diet, and host physiology. Prebiotics are substrates that are selectively utilized by host microorganisms, conferring health benefits. Prebiotics, such as prebiotic blends (PB), are commonly used worldwide in food processing. Here, microbiome-metabolomics was used to evaluate how PB affect gut microbes and metabolic functions in C57BL/6 J mice administered cefixime. We found favorable effects of PB on obesity outcomes. PB supplementation significantly increased the abundance of Bifidobacterium, Parabacteroides, Alloprevotella, Alistipes, and Dubosiella, and decreased that of Robinsoniella, Blautia, Lachnoclostridium, Coprobacillus, Hungatella, Erysipelatoclostridium, Helicobacter, Clostridium sensu stricto 1, Enterococcus, and Akkermansia compared to that in the cefixime administration (CEF) group. In particular, PB increased the abundance of Parabacteroides goldsteinii and suppressed that of Robinsoniella peoriensis and Akkermansia muciniphila. In addition, it regulated the levels of microbial metabolites such as unsaturated fatty acids and bile acids. Thus, PB can alleviate metabolic disorders induced by antibiotic intervention, indicating a potential dietary strategy for populations with antibiotic-associated diarrhea.
WOS关键词	DIARRHEA
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
WOS记录号	WOS:000819890400003
资助机构	Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Program of Yantai
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31011]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者	Li, Lili
作者单位	1.Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Jingyi,Qin, Song,Hu, Shanliang,et al. Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2022:13.
APA	Yuan, Jingyi,Qin, Song,Hu, Shanliang,Liu, Zhengyi,Song, Yipeng,&Li, Lili.(2022).Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,13.
MLA	Yuan, Jingyi,et al."Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2022):13.