Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation

doi:10.3390/jmse10030428

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation
	Cao, Xuwen 1,2,3,4,5; Sun, Peiqi 1,2,3,4,5; Zhang, Liusuo 1,2,3,4
刊名	JOURNAL OF MARINE SCIENCE AND ENGINEERING
	2022-03-01
卷号	10 期号:3 页码:17
关键词	marine nematode stearic acid CeMM development transcriptome protein translation neuronal signaling
DOI	10.3390/jmse10030428
通讯作者	Zhang, Liusuo(lzhang@qdio.ac.cn)
英文摘要	Stearic acid represents one of the most abundant fatty acids in the Western diet and profoundly regulates health and diseases of animals and human beings. We previously showed that stearic acid supplementation promoted development of the terrestrial model nematode Caenorhabditis elegans in chemically defined CeMM food environment. However, whether stearic acid regulates development of other nematodes remains unknown. Here, we found that dietary supplementation with stearic acid could promote the development of the marine nematode Litoditis marina, belonging to the same family as C. elegans, indicating the conserved roles of stearic acid in developmental regulation. We further employed transcriptome analysis to analyze genome-wide transcriptional signatures of L. marina with dietary stearic acid supplementation. We found that stearic acid might promote development of L. marina via upregulation of the expression of genes involved in aminoacyl-tRNA biosynthesis, translation initiation and elongation, ribosome biogenesis, and transmembrane transport. In addition, we observed that the expression of neuronal signaling-related genes was decreased. This study provided important insights into how a single fatty acid stearic acid regulates development of marine nematode, and further studies with CRISPR genome editing will facilitate demonstrating the molecular mechanisms underlying how a single metabolite regulates animal development and health.
资助项目	National Key R and D Program of China[2018YFD0901301] ; Talents from overseas Program, IOCAS of the Chinese Academy of Sciences ; Qingdao Innovation Leadership Program[16-8-3-19-zhc] ; Key deployment project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences[COMS2019Q16]
WOS研究方向	Engineering ; Oceanography
语种	英语
出版者	MDPI
WOS记录号	WOS:000774852900001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/178642]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Zhang, Liusuo
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cao, Xuwen,Sun, Peiqi,Zhang, Liusuo. Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation[J]. JOURNAL OF MARINE SCIENCE AND ENGINEERING,2022,10(3):17.
APA	Cao, Xuwen,Sun, Peiqi,&Zhang, Liusuo.(2022).Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation.JOURNAL OF MARINE SCIENCE AND ENGINEERING,10(3),17.
MLA	Cao, Xuwen,et al."Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation".JOURNAL OF MARINE SCIENCE AND ENGINEERING 10.3(2022):17.