An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy

doi:10.1016/j.talanta.2021.123111

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy
	Lu, Pengpeng 2,3; Huang, Yan 2,3; Zhang, Caiyun 3; Fu, Lili 2,3; Wang, Xiaoyan 2,3; Chen, Lingxin 1,2,3
刊名	TALANTA
	2022-03-01
卷号	239 页码:9
关键词	Cytochrome P450 Fluorescence imaging Chemotherapy Liver cancer
ISSN号	0039-9140
DOI	10.1016/j.talanta.2021.123111
通讯作者	Huang, Yan(yhuang@yic.ac.cn) ; Wang, Xiaoyan(wangxy@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Cancer is a complex disease with very high incidence and mortality rates every year. However, cancer drug resistance greatly mitigates the cure rates of tumors, and cytochrome P450 (CYP450) plays an important role in the development of cisplatin resistance. We developed the aggregation-induced emission luminogen (AIEgen) TPE-CYP to monitor the changes in CYP450. The TPE-CYP fluorescent probe was successfully used to assess CYP450 levels in tumor cells and tumor tissue sections. This study presented that CYP450 level in HepG2/DDP cells (cisplatin-resistant cells) was higher than that in HepG2 cells, and the inhibition of CYP450 by 1-ABT effectively improved the tumor resistance. Thus, CYP450 plays a key role in the development of tumor resistance. The synergistic effect of 1-ABT and the chemotherapeutic agent cisplatin was superior to that of cisplatin alone in tumor-bearing mice. The TPE-CYP probe will provide an idea for the clinical implementation of individualized tumor treatment strategies, through the accurate monitoring of CYP450.
WOS关键词	CYTOCHROME-P450 ISOFORMS ; DRUG-RESISTANCE ; PRODRUG AQ4N ; N-OXIDES ; THERAPY ; HYPOXIA ; ACTIVATION ; EXPRESSION ; METABOLISM ; MECHANISMS
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000729414400006
资助机构	National Nature Science Foundation of China ; science and technology innovation development plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/30962]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Huang, Yan; Wang, Xiaoyan; Chen, Lingxin
作者单位	1.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Lu, Pengpeng,Huang, Yan,Zhang, Caiyun,et al. An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy[J]. TALANTA,2022,239:9.
APA	Lu, Pengpeng,Huang, Yan,Zhang, Caiyun,Fu, Lili,Wang, Xiaoyan,&Chen, Lingxin.(2022).An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy.TALANTA,239,9.
MLA	Lu, Pengpeng,et al."An aggregation-induced emission fluorescence probe for evaluating the effect of CYP450 changes under tumor chemotherapy".TALANTA 239(2022):9.