New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release

doi:10.1016/j.carbpol.2021.118623

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release
	Mi, Yingqi 3,4,5; Chen, Yuan 2; Gu, Guodong 1; Miao, Qin 3,4,5; Tan, Wenqiang 4,5; Li, Qing 4,5; Guo, Zhanyong 3,4,5
刊名	CARBOHYDRATE POLYMERS
	2021-12-01
卷号	273 页码:11
关键词	Chitosan Drug release Cell viability Antitumor activity
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2021.118623
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	In this paper, adriamycin-incorporated chitosan nanoparticles were synthesized by ionic gelation using negatively charged carboxymethyl chitosan and positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan. The method was efficient to obtain nanoparticles with low polydispersity index and small hydrodynamic diameter. And high zeta potential value indicated that nanoparticles had good stability. The adriamycin release of nanoparticles represented a significant response to pH, with the fastest release in phosphate buffer solution at pH 6.8. Meanwhile, the antioxidant efficiency of nanoparticles was assayed, and nanoparticles represented significant enhancement in radicals scavenging activity. The assay of cell viability by CCK-8 test exhibited that nanoparticles led to statistically significant decrease in cell viability for four kinds of cancer cells (HEPG-2, A549, MCF-7, and BGC-823). It was indicated that the nanoparticles with enhanced biological activity, reduced cytotoxicity, and pH-sensitive release could be served as potential drug carrier in drug delivery system.
WOS关键词	CARBOXYMETHYL CHITOSAN ; CYTOTOXICITY ; DELIVERY ; CHLORIDE ; SULFATE
WOS研究方向	Chemistry ; Polymer Science
语种	英语
WOS记录号	WOS:000704406600003
资助机构	National Key R&D Program of China ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shangdong Province of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/30781]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Guo, Zhanyong
作者单位	1.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA 2.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Mi, Yingqi,Chen, Yuan,Gu, Guodong,et al. New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release[J]. CARBOHYDRATE POLYMERS,2021,273:11.
APA	Mi, Yingqi.,Chen, Yuan.,Gu, Guodong.,Miao, Qin.,Tan, Wenqiang.,...&Guo, Zhanyong.(2021).New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release.CARBOHYDRATE POLYMERS,273,11.
MLA	Mi, Yingqi,et al."New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release".CARBOHYDRATE POLYMERS 273(2021):11.