Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry

doi:10.1039/d0nr09115d

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	Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry
	G. Xiang; Q. Xia; X. Liu; Y. Wang; S. Jiang; L. Li; X. Zhou; L. Ma; X. Wang and J. Zhang
刊名	Nanoscale
	2021
卷号	13 期号:15 页码:7161-7168
ISSN号	20403364
DOI	10.1039/d0nr09115d
英文摘要	Highly effective photothermal conversion performance coupled with high resolution temperature detection in real time is urgently needed for photothermal therapy (PTT). Herein, ultra-small Cu2S nanoparticles (NPs) were designed to absorb on the surface of NaScF4: Yb3+/Er3+/Mn2+@NaScF4@SiO2 NPs to form a central-satellite system, in which the Cu2S NPs play the role of providing significant light-to-heat conversion ability and the Er3+ ions in the NaScF4: Yb3+/Er3+/Mn2+ cores act as a thermometric probe based on the fluorescence intensity ratio (FIR) technology operating in the biological windows. A wavelength of 915 nm is used instead of the conventional 980 nm excitation wavelength to eliminate the laser induced overheating effect for the bio-tissues, by which Yb3+ can also be effectively excited. The temperature resolution of the FIR-based optical thermometer is determined to be better than 0.08 K over the biophysical temperature range with a minimal value of 0.06 K at 298 K, perfectly satisfying the requirements of biomedicine. Under the radiation of 915 nm light, the Cu2S NPs exhibit remarkable light-to-heat conversion capacity, which is proved by photothermal ablation testing of E. coli. The results reveal the enormous potential of the present NPs for PTT integrated with real-time temperature sensing with high resolution. This journal is The Royal Society of Chemistry.
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内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/65736]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	G. Xiang,Q. Xia,X. Liu,et al. Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry[J]. Nanoscale,2021,13(15):7161-7168.
APA	G. Xiang.,Q. Xia.,X. Liu.,Y. Wang.,S. Jiang.,...&X. Wang and J. Zhang.(2021).Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry.Nanoscale,13(15),7161-7168.
MLA	G. Xiang,et al."Upconversion nanoparticles modified by Cu2S for photothermal therapy along with real-time optical thermometry".Nanoscale 13.15(2021):7161-7168.