Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.

doi:10.1007/s00253-022-11914-1

	Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.
	Hong, Xuan 1; Guan, Xiaoqing 3; Lai, Qiliang 2; Yu, Dehua 3; Chen, Zhongwei 1; Fu, Xiaoteng 2; Zhang, Beibei 2; Chen, Changkun 1; Shao, Zongze 2; Xia, Jinmei 2
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2022-04-01
卷号	106
关键词	Talaromyces Meroterpenoid Cytotoxic Antibacterial
ISSN号	0175-7598
DOI	10.1007/s00253-022-11914-1
通讯作者	Xia, Jinmei(xiajinmei@tio.org.cn) ; Qin, Jiang-Jiang(jqin@ucas.ac.cn) ; Wang, Weiyi(wywang@tio.org.cn)
英文摘要	A new meroterpenoid, taladrimanin A (1), was isolated from a marine-derived fungus Talaromyces sp. HM6-1-1, together with eleven biogenetically related compounds (2-12). A plausible biosynthetic pathway for the meroterpenoids (1-4) was proposed. The planar structure of 1 was assigned by HRESIMS and NMR. Its relative configuration was established by quantum chemical NMR calculation of two possible isomers and analyzed by DP4 + method. Finally, X-ray diffraction unambiguously confirmed the relative configuration and revealed the absolute configuration of compound 1. 2-12 were assigned by comparing their NMR data with those reported in the literature. 1 was the first drimane-type meroterpenoid with a C10 polyketide unit bearing an 8R-configuration. In the bioactive assay, 1 exhibited antitumor activity against gastric cancer cells MGC803 and MKN28; it also inhibited the colony formation and induced apoptosis in MGC803 cells both in a concentration-dependent manner. Additionally, 1 displayed selective antibacterial activity against Staphylococcus aureus 6538P, and low activities towards strains of Vibrio parahaemolyticus and Escherichia coli in this study.
资助项目	Natural Science Foundation of Fujian Province[2021J01509] ; Scientific Research Foundation of Third Institute of Oceanography SOA[2018021] ; National Natural Science Foundation of China[81903842] ; National Natural Science Foundation of China[41906104] ; Deep Sea Habitats Discovery Project[DY-XZ-04] ; Research project on education and teaching reform in undergraduate colleges and universities of Fujian Province[FBJG20190201] ; Natural Science Foundation of Zhejiang Province[LR21H280001] ; Natural Science Foundation of Zhejiang Province[Q22H287247] ; COMRA program[DY135-B2-01] ; COMRA program[DY135B2-05] ; Scientific Research Foundation of Third Institute of Oceanography MNR[2019021]
WOS关键词	LIPID DROPLET FORMATION ; ABSOLUTE STEREOCHEMISTRY ; MOUSE MACROPHAGES ; PENICILLIUM ; INHIBITORS ; PENTACECILIDES ; IDENTIFICATION
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000783453900003
资助机构	Natural Science Foundation of Fujian Province ; Scientific Research Foundation of Third Institute of Oceanography SOA ; National Natural Science Foundation of China ; Deep Sea Habitats Discovery Project ; Research project on education and teaching reform in undergraduate colleges and universities of Fujian Province ; Natural Science Foundation of Zhejiang Province ; COMRA program ; Scientific Research Foundation of Third Institute of Oceanography MNR
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128619]
专题	中国科学院合肥物质科学研究院
通讯作者	Xia, Jinmei; Qin, Jiang-Jiang; Wang, Weiyi
作者单位	1.Xiamen Med Coll, Fujian Univ & Coll Engn Res Ctr Marine Biopharmac, Xiamen 361023, Peoples R China 2.Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen 361005, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Hong, Xuan,Guan, Xiaoqing,Lai, Qiliang,et al. Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2022,106.
APA	Hong, Xuan.,Guan, Xiaoqing.,Lai, Qiliang.,Yu, Dehua.,Chen, Zhongwei.,...&Wang, Weiyi.(2022).Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp..APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,106.
MLA	Hong, Xuan,et al."Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 106(2022).