Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans

doi:10.3390/toxics10030133

	Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans
	Pei, Chengcheng 1,2; Sun, Lingyan 1,2; Zhao, Yanan 1,2; Ni, Shenyao 1,2; Nie, Yaguang 1,2; Wu, Lijun 1,2; Xu, An 1,2,3,4
刊名	TOXICS
	2022-03-01
卷号	10
关键词	cadmium arsenic species joint toxicity C. elegans bioaccumulation
DOI	10.3390/toxics10030133
通讯作者	Nie, Yaguang(nyg@ahu.edu.cn) ; Xu, An(anxu@ipp.ac.cn)
英文摘要	Cadmium (Cd) and arsenic (As) are widely distributed pollutants that co-exist in the environment; however, their joint toxicity on living organisms is still largely unknown. In this study, we explored the joint toxicity of concurrent exposure to Cd and different As species at low concentrations on Caenorhabditis elegans (C. elegans) in comparison to single exposures. Endpoints such as germ cell apoptosis, the number of oocytes, brood size, and the life span were employed to evaluate the combined effects of Cd and As on exposed C. elegans from L3 or L4 stages. Our results showed that concurrent exposure to non-toxic concentrations of Cd and As caused the synergy of reproductive and developmental toxicity. The presence of Cd promoted the accumulation of As in both germline and intestine detected by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Although a conversion of As(III) to As(V) was detected as dependent on pH according to the microenvironment of the intestine in the worm, there was no significant difference of toxicity in C. elegans concurrently exposed to Cd and different As species. Using loss-of-function mutant strains, As was deemed responsible for the enhanced joint toxicity, and in which gcs-1 played a key protective role. These data help to better evaluate the comprehensive adverse effects of concurrent exposure of heavy metals at low concentrations on living organisms in the environment.
资助项目	Anhui Provincial Key Research and Development Programs[202004i07020015] ; Anhui Provincial Key Research and Development Programs[202004i07020016] ; Open Fund of Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Institute of Technical Biology and Agriculture Engineering, Hefei Institutes of Physical Science, CAS[2019-3] ; National Key Research and Development Program of China[2020YFC1808204]
WOS关键词	INDUCED GERMLINE APOPTOSIS ; REPRODUCTIVE TOXICITY ; SODIUM ARSENITE ; HUMAN HEALTH ; LIFE-SPAN ; EXPOSURE ; CELL ; GLUTATHIONE ; DEFENSE ; MIXTURE
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
语种	英语
出版者	MDPI
WOS记录号	WOS:000774461800001
资助机构	Anhui Provincial Key Research and Development Programs ; Open Fund of Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Institute of Technical Biology and Agriculture Engineering, Hefei Institutes of Physical Science, CAS ; National Key Research and Development Program of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128191]
专题	中国科学院合肥物质科学研究院
通讯作者	Nie, Yaguang; Xu, An
作者单位	1.Anhui Univ, Inst Phys Sci, Informat Mat & Intelligent Sensing Lab Anhui Prov, Hefei 230601, Peoples R China 2.Anhui Univ, Inst Informat Technol, Informat Mat & Intelligent Sensing Lab Anhui Prov, Hefei 230601, Peoples R China 3.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 4.Chinese Acad Sci, Anhui Prov Key Lab Environm Toxicol & Pollut Cont, High Magnet Field Lab, Hefei Inst Phys Sci, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Pei, Chengcheng,Sun, Lingyan,Zhao, Yanan,et al. Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans[J]. TOXICS,2022,10.
APA	Pei, Chengcheng.,Sun, Lingyan.,Zhao, Yanan.,Ni, Shenyao.,Nie, Yaguang.,...&Xu, An.(2022).Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans.TOXICS,10.
MLA	Pei, Chengcheng,et al."Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans".TOXICS 10(2022).