Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study

doi:10.1016/j.jbspin.2020.09.010

CORC > 自动化研究所 > 中国科学院自动化研究所 > 复杂系统管理与控制国家重点实验室 > 先进控制与自动化团队

	Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study
	Gao, Qianhui 1,7; Cheng, Xiaoyu 1,7; Merriman, Tony R.4,5,6; Wang, Can 1,7; Cui, Lingling 1,7; Zhang, Hui 6; Sun, Wenyan 6; Wang, Jing 2,3; Wang, Feiyue 2,3; Li, Changgui 1,6,7
刊名	JOINT BONE SPINE
	2021-12-01
卷号	88 期号:6 页码:6
关键词	Gout Early-onset Risk factors
ISSN号	1297-319X
DOI	10.1016/j.jbspin.2020.09.010
通讯作者	Lu, Jie(13127006046@163.com)
英文摘要	Objective: The prevalence of gout is increasing but studies of its clinical features in large samples are lacking. This study aimed to clarify changes in the clinical manifestations of gout in China over the last decade and investigate the clinical features and risk factors of early-onset gout. Methods: Clinical manifestations were compared between 9754 gout patients who first presented at our clinic with gout in 2008-2012 (earlier group) or 2013-2018 (later group). Gout onset <= 30 years old was defined as early-onset and > 30 years as late-onset. Clinical features and risk factors were compared between the groups. Results: The gout-onset age was 4.14 years younger and the percentage of early-onset gout (3827 patients) was higher in the later 2013-2018 group (5979 patients). The disease duration was significantly shorter (5.72 +/- 0.09 vs. 6.01 +/- 0.11 years P < 0,05) and the ratio of patients with tophi was correspondingly lower in the later group (22.0% vs. 20.0%, P < 0,05). More patients were obese (32.6% vs. 37.7%, P < 0.001) and serum urate levels (465.0 +/- 1.9 mu mol/L vs. 485.5 +/- 1.5 mu mol/L) were significantly higher in the later group. As the age of gout-onset became younger, we did the multivariate logistic regression and identified a positive family history, male sex, obesity, elevated serum urate, and sugar-sweetened soft drinks as independent predictors of early-onset gout. Conclusion: The manifestations of gout in China have changed over the last decade, associated with trend towards younger onset. (C) 2020 Socie acute accent te acute accent franc , aise de rhumatologie. Published by Elsevier Masson SAS.
资助项目	National Key Research and Development Program[2016YFC0903400] ; National Natural Science Foundation of China[31900413] ; National Natural Science Foundation of China[81520108007] ; National Natural Science Foundation of China[81770869]
WOS关键词	URIC-ACID ; YOUNGER AGE ; HYPERURICEMIA ; OBESITY ; ONSET ; RISK ; PREVALENCE
WOS研究方向	Rheumatology
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000722025600001
资助机构	National Key Research and Development Program ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/46542]
专题	自动化研究所_复杂系统管理与控制国家重点实验室_先进控制与自动化团队
通讯作者	Lu, Jie
作者单位	1.Qingdao Univ, Affiliated Hosp, Dept Endocrinol & Metab, Shandong Prov Key Lab Metab Dis, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 3.Qingdao Acad Intelligent Ind, Inst Smart Healthcare Syst, Qingdao 266109, Peoples R China 4.Univ Alabama Birmingham, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA 5.Univ Otago, Dept Biochem, Dunedin, New Zealand 6.Qingdao Univ, Inst Metab Dis, Qingdao 266003, Peoples R China 7.Qingdao Univ, Affiliated Hosp, Dept Endocrinol & Metab, Qingdao Key Lab Gout, Qingdao 266003, Peoples R China
推荐引用方式 GB/T 7714	Gao, Qianhui,Cheng, Xiaoyu,Merriman, Tony R.,et al. Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study[J]. JOINT BONE SPINE,2021,88(6):6.
APA	Gao, Qianhui.,Cheng, Xiaoyu.,Merriman, Tony R..,Wang, Can.,Cui, Lingling.,...&Lu, Jie.(2021).Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study.JOINT BONE SPINE,88(6),6.
MLA	Gao, Qianhui,et al."Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study".JOINT BONE SPINE 88.6(2021):6.