It is an urgent need to develop a new catalyst with high efficiency and low cost. In the present study, we successfully prepared bimetallic-supported denitration catalysts using the blast furnace slag as the main material and calcium bentonite as the binder. The as-prepared catalyst was characterized via X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Besides, the mechanism of denitration was further determined with the help of the denitration and sulfur resistance of the catalyst. The results indicated that when the Mn load was 5%, and the second metal reactive component was loaded at 3%, Mn-Cu/GGBS (catalyst prepared by loading Mn and Cu on the blast furnace slag) had the best effects on low temperature denitration. Moreover, the conversion rate of NO was up to 97%, and it possessed the capability of specific sulfur resistance; when the third metal reactive component, Ce, was introduced with 1% load, the sulfur resistance of the Mn-Cu-Ce/GGBS (catalyst prepared by loading Mn, Cu, and Ce on the blast furnace slag) catalyst was further improved compared with that of the Mn-Cu/GGBS catalyst.