A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy | |
Li, Xiaozhen3; Zhang, Di4,5; Yin, Chao1,6; Lu, Guihong7; Wan, Yingpeng3; Huang, Zhongming3; Tan, Jihua3; Li, Shengliang2,3; Luo, Jingdong4,5; Lee, Chun-Sing3 | |
刊名 | ACS APPLIED MATERIALS & INTERFACES |
2021-04-14 | |
卷号 | 13期号:14页码:15983-15991 |
关键词 | Diradical Near-infrared Small Molecule Photoacoustic Imaging Photothermal Therapy |
ISSN号 | 1944-8244 |
DOI | 10.1021/acsami.0c21889 |
英文摘要 | Organic small molecule-based phototheranostics hold great promise for clinical translation by virtue of their distinct chemical structure, easy reproducibility, and high purity. However, reported molecular agents typically have relatively low optical absorbances, particularly over the near-infrared (NIR) region, and this limits their phototheranostic performance. Herein, we first exploit a diradicaloid molecular structure for enhancing NIR absorption to facilitate efficient photoacoustic imaging (PAI)-guided photothermal therapy (PTT). The donor-acceptor interaction in the diradicaloid molecule (DRM) leads to strong charge transfer resulting on obvious diradical characteristics, which is beneficial for NIR absorption. The DRM possesses excellent light-harvesting ability, with a mass extinction coefficient of similar to 220 L g(-1) cm(-1), which is much higher than those (similar to 5-100 L g(-1) cm(-1)) of typical organic molecules. After assembling into nanoparticles, they show good water dispersibility, good photostability, and impressive performance for PAI-guided PTT in vitro and in vivo. The impressive in vitro and in vivo performances show that developing small molecules with diradicaloid structures can be an effective approach for enhancing NIR harvesting capability for biomedical applications. |
资助项目 | ARG-CityU Applied Research Grant[9667160] ; ARG-CityU Applied Research Grant[9667179] ; University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China[JLFS/P-101/18] ; Natural Science Foundation of China[21975213] ; Natural Science Foundation of China[62005127] ; Shenzhen Science & Technology Innovation Committee[JCYJ20180507181718203] ; General Research Fund of HKSAR (RGC)[11306320] ; City University of Hong Kong[9610389] ; City University of Hong Kong[9610454] ; City University of Hong Kong[9680263] ; National Natural Science Foundation of China[32000988] ; China Postdoctoral Science Foundation[2019TQ0212] ; China Postdoctoral Science Foundation[2020M672832] ; Nanjing University of Posts & Telecommunications[NY220068] |
WOS关键词 | Semiconducting Polymer Nanoparticles ; Nanomaterials ; Energy ; Dots |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000641156600003 |
资助机构 | ARG-CityU Applied Research Grant ; University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China ; Natural Science Foundation of China ; Shenzhen Science & Technology Innovation Committee ; General Research Fund of HKSAR (RGC) ; City University of Hong Kong ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Nanjing University of Posts & Telecommunications |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/48688] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Lu, Guihong; Li, Shengliang; Luo, Jingdong; Lee, Chun-Sing |
作者单位 | 1.Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China 2.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China 3.City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Dept Chem, Kowloon, Hong Kong, Peoples R China 4.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China 5.City Univ Hong Kong, Shenzhen Res Inst, Kowloon, Hong Kong, Peoples R China 6.Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China 7.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Xiaozhen,Zhang, Di,Yin, Chao,et al. A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(14):15983-15991. |
APA | Li, Xiaozhen.,Zhang, Di.,Yin, Chao.,Lu, Guihong.,Wan, Yingpeng.,...&Lee, Chun-Sing.(2021).A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,13(14),15983-15991. |
MLA | Li, Xiaozhen,et al."A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 13.14(2021):15983-15991. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论