Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy

doi:10.1002/adma.202100595

	Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy
	Li, Shukun 1,3; Zhang, Wenjia 2; Xing, Ruirui 1; Yuan, Chengqian 1; Xue, Huadan 2; Yan, Xuehai 1,3
刊名	ADVANCED MATERIALS
	2021-04-19
页码	9
关键词	cancer peptides photosensitizers photothermal immunotherapy self‐ assembly
ISSN号	0935-9648
DOI	10.1002/adma.202100595
英文摘要	Pancreatic cancer, one of the most lethal malignancies, compromises the performance of traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a biocompatible therapeutic paradigm that can effectively inhibit pancreatic tumor growth while simultaneously eliminating tumor metastasis is urgently needed. Herein, supramolecular nanofibrils are fabricated through coassembly of clinically approved immunomodulatory thymopentin and near-infrared indocyanine green for localized photothermal immunotherapy of pancreatic tumors. The resulting long-range ordered fibrous nanodrugs show improved photophysical capabilities for fluorescence imaging and photothermal conversion and significantly promote the proliferation and differentiation of antitumor immune cells. Hence, the integration of rapid photothermal therapy and moderate immunomodulation for inhibiting tumor growth and eliminating tumor metastasis is promising. The utilization of clinically approved molecules to construct nanodrugs administered via localized injection amplifies the complementary photothermal immunotherapeutic effects of the components, creating opportunities for clinical translation as a treatment for pancreatic cancer.
资助项目	National Science Fund for Distinguished Young Scholars of China[22025207] ; National Natural Science Foundation of China[22072154] ; National Natural Science Fund BRICS STI Framework Program of China[51861145304] ; Innovation Research Community Science Fund of China[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000641165700001
资助机构	National Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Program of China ; Innovation Research Community Science Fund of China ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/48251]
专题	中国科学院过程工程研究所
通讯作者	Xing, Ruirui; Xue, Huadan; Yan, Xuehai
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Peking Union Med Coll Hosp, Dept Radiol, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China
推荐引用方式 GB/T 7714	Li, Shukun,Zhang, Wenjia,Xing, Ruirui,et al. Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy[J]. ADVANCED MATERIALS,2021:9.
APA	Li, Shukun,Zhang, Wenjia,Xing, Ruirui,Yuan, Chengqian,Xue, Huadan,&Yan, Xuehai.(2021).Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy.ADVANCED MATERIALS,9.
MLA	Li, Shukun,et al."Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy".ADVANCED MATERIALS (2021):9.