Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition

doi:10.1016/j.bioactmat.2020.07.006

	Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition
	Lu, Zhiguo 1,3; Wang, Jianze 1; Qu, Lina 2; Kan, Guanghan 2; Zhang, Tianlu 1,3; Shen, Jie 1,3; Li, Yan 1; Yang, Jun 1; Niu, Yunwei 4,5; Xiao, Zuobing 4,5
刊名	BIOACTIVE MATERIALS
	2020-12-01
卷号	5 期号:4 页码:1127-1137
关键词	Reactive mesoporous silica nanoparticles Slow release of limonene Simulated microgravity condition Improvement of physical health Improvement of mental health
DOI	10.1016/j.bioactmat.2020.07.006
英文摘要	Astronauts are under high stress for a long time because of the microgravity condition, which leads to anxiety, affects their learning and memory abilities, and seriously impairs the health of astronauts. Aromatherapy can improve the physical and mental health of astronauts in a way that moisturizes them softly and silently. However, the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of spaceflight. In this study, reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release limonene. The limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride (LE@MSNs-CYC). LE@MSNs-CYC were then applied to wallpaper to improve the convenience of aromatherapy. LE@MSNs-CYC could chemically react with the wallpaper, thus firmly adsorbed on the wallpaper. In the following, the mice were treated with hindlimb unloading (HU) to simulate a microgravity environment. The results showed that 28-day HU led to an increase in the level of anxiety and declines in learning, memory, and physical health in mice. LE@MSNs-CYC showed significant relief effects on anxiety, learning, memory, and physical health of HU treated mice. Subsequently, the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones, immune-related cytokines, learning, and memory-related neurotransmitters and proteins.
资助项目	National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046,2192057] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283]
WOS关键词	ELEVATED PLUS-MAZE ; HPA-AXIS ; STRESS-RESPONSE ; SPATIAL MEMORY ; ESSENTIAL OILS ; ANXIETY ; FRAGRANCE ; CARRIERS ; PRODRUG ; SYSTEM
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	KEAI PUBLISHING LTD
WOS记录号	WOS:000562478100033
资助机构	National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41774]
专题	中国科学院过程工程研究所
通讯作者	Li, Yinghui; Zhang, Xin
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.China Astronaut Res & Training Ctr, State Key Lab Space Med Fundamentals & Applicat, Beijing 100094, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China 5.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
推荐引用方式 GB/T 7714	Lu, Zhiguo,Wang, Jianze,Qu, Lina,et al. Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition[J]. BIOACTIVE MATERIALS,2020,5(4):1127-1137.
APA	Lu, Zhiguo.,Wang, Jianze.,Qu, Lina.,Kan, Guanghan.,Zhang, Tianlu.,...&Zhang, Xin.(2020).Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition.BIOACTIVE MATERIALS,5(4),1127-1137.
MLA	Lu, Zhiguo,et al."Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition".BIOACTIVE MATERIALS 5.4(2020):1127-1137.