Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy

doi:10.1016/j.colsurfa.2020.124486

	Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy
	Li, Hong 1; Zhao, Jie 2; Wang, Anhe 3; Li, Qi 3; Cui, Wei 2
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2020-04-05
卷号	590 页码:6
关键词	TRAIL Diphenylalanine Self-assembly Cancer therapy
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2020.124486
英文摘要	Molecular self-assembly of functional proteins has garnered intense interest for the development of nanomaterials. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as one of the most promising agents for cancer therapy, could selectively induce the apoptotic cell death in tumor cells while not on normal cells. In this study, protein-based nanoparticles were constructed with TRAIL and a dipeptide, diphenylalanine (FF), through molecular self-assembly. TRAIL-FF nanoparticles with sizes ranging from 60 nm to 500 nm could be prepared by controlling the concentration and the ratio of the two components. These nanoparticles could locate around the cytomembrane of MCF-7 cells due to the specific interaction between TRAIL and death receptors, thus transduce apoptotic signal. Therefore, the TRAIL-FF nanoparticles showed distinct killing effect on the cancer cells, such as MCF-7 and H460 cells, and the IC50 of the nanoparticles on H460 cells was about 260 ng/mL. The approach presented herein may be applicable to the fabrication of an extended range of protein-based functional biomaterials.
资助项目	National Natural Science Foundation of China[21872150] ; National Natural Science Foundation of China[21433010] ; National Natural Science Foundation of China[21703169] ; National Natural Science Foundation of China[2191101022] ; Natural Science Foundation of Shaanxi Province of China[2018JQ2047] ; Young Talent fund of University Association for Science and Technology in Shaanxi Province of China[20190605]
WOS关键词	DOPAMINE ; PEPTIDE ; NANOSTRUCTURES ; MICROCAPSULES ; CONSTRUCTION ; FABRICATION
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000513862500012
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shaanxi Province of China ; Young Talent fund of University Association for Science and Technology in Shaanxi Province of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39563]
专题	中国科学院过程工程研究所
通讯作者	Cui, Wei
作者单位	1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 710065, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Hong,Zhao, Jie,Wang, Anhe,et al. Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,590:6.
APA	Li, Hong,Zhao, Jie,Wang, Anhe,Li, Qi,&Cui, Wei.(2020).Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,590,6.
MLA	Li, Hong,et al."Supramolecular assembly of protein-based nanoparticles based on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) for cancer therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 590(2020):6.