Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF beta signaling

doi:10.1038/s41388-021-02098-5

	Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF beta signaling
	Kong, Ya 1,2; Zhang, Yutian 1,2; Wang, Hanlin 1,3; Kan, Weijuan 1; Guo, Haoran 1,2; Liu, Yun 4; Zang, Yi 1,2,5; Li, Jia 1,2,5,6
刊名	ONCOGENE
	2021-11-19
页码	10
ISSN号	0950-9232
DOI	10.1038/s41388-021-02098-5
通讯作者	Zang, Yi(yzang@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn)
英文摘要	Emerging evidence shows the association between nuclear envelope and tumor progression, however, the functional contributions of specific constituents of the nuclear envelope remain largely unclear. We found that the expression level of transmembrane protein 201 (TMEM201), an integral inner nuclear membrane protein of unknown function, was significantly elevated in invasive breast cancer and predicted poor breast cancer prognosis. We showed that TMEM201, as a positive modulator, was both necessary and sufficient to regulate the migration and invasion of breast cancer cells in vitro and in vivo. Mechanistically, RNA-sequencing analysis and validation showed that TMEM201 deficiency inhibited epithelial-to-mesenchymal transition and transforming growth factor-beta signaling. Finally, we showed that TMEM201 physically interacted with SMAD2/3 and was required for the phosphorylation of SMAD2/3, nuclear translocation and transcriptional activation of the TGF beta. Thus, we demonstrated that specific inner nuclear membrane component mediated signal-dependent transcriptional effects to control breast cancer metastasis.
资助项目	National Natural Science Foundation of China[31871414] ; National Natural Science Foundation of China[81971265] ; Science and Technology Commission of Shanghai Municipality[19JC1416300] ; Shanghai Institute of Materia Medica[SIMM2004KF-01] ; Shanghai Municipal Human Resources and Social Security Bureau[Y91204R]
WOS关键词	INTEGRAL PROTEIN ; MAN1 ; REVEALS ; LAMINA ; SAMP1
WOS研究方向	Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
语种	英语
出版者	SPRINGERNATURE
WOS记录号	WOS:000720611600002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/299009]
专题	中国科学院上海药物研究所
通讯作者	Zang, Yi; Li, Jia
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Fudan Univ, Dept Pharmacol, Shanghai 201203, Peoples R China 4.China Pharmaceut Univ, State Key Lab Nat Med, Jiangsu Key Lab Drug Screening, 24 Tong Jia Xiang St, Nanjing 210009, Peoples R China 5.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou, Peoples R China 6.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Kong, Ya,Zhang, Yutian,Wang, Hanlin,et al. Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF beta signaling[J]. ONCOGENE,2021:10.
APA	Kong, Ya.,Zhang, Yutian.,Wang, Hanlin.,Kan, Weijuan.,Guo, Haoran.,...&Li, Jia.(2021).Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF beta signaling.ONCOGENE,10.
MLA	Kong, Ya,et al."Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGF beta signaling".ONCOGENE (2021):10.