The double faced role of xanthine oxidoreductase in cancer

doi:10.1038/s41401-021-00800-7

	The double faced role of xanthine oxidoreductase in cancer
	Chen, Man-Man 1,2; Meng, Ling-Hua 1,2
刊名	ACTA PHARMACOLOGICA SINICA
	2021-11-22
页码	10
关键词	xanthine oxidoreductase (XOR) ROS uric acid cancer therapy
ISSN号	1671-4083
DOI	10.1038/s41401-021-00800-7
通讯作者	Meng, Ling-Hua(lhmeng@simm.ac.cn)
英文摘要	Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. It also produces reactive oxygen species (ROS) during the catalytic process. The enzyme is generally recognized as a drug target for the therapy of gout and hyperuricemia. The catalytic products uric acid and ROS act as antioxidants or oxidants, respectively, and are involved in pro/anti-inflammatory actions, which are associated with various disease manifestations, including metabolic syndrome, ischemia reperfusion injury, cardiovascular disorders, and cancer. Recently, extensive efforts have been devoted to understanding the paradoxical roles of XOR in tumor promotion. Here, we summarize the expression of XOR in different types of cancer and decipher the dual roles of XOR in cancer by its enzymatic or nonenzymatic activity to provide an updated understanding of the mechanistic function of XOR in cancer. We also discuss the potential to modulate XOR in cancer therapy.
资助项目	National Natural Science Foundation of China[81773760] ; National Natural Science Foundation of China[81973345]
WOS关键词	TUMOR LYSIS SYNDROME ; SERUM URIC-ACID ; OXIDATIVE STRESS ; OXIDASE INHIBITORS ; PROSTATE-CANCER ; MAMMARY-GLAND ; BREAST-CANCER ; SUPEROXIDE-DISMUTASE ; RAT MODEL ; CELL
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	NATURE PUBL GROUP
WOS记录号	WOS:000721428700004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/299000]
专题	中国科学院上海药物研究所
通讯作者	Meng, Ling-Hua
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Man-Man,Meng, Ling-Hua. The double faced role of xanthine oxidoreductase in cancer[J]. ACTA PHARMACOLOGICA SINICA,2021:10.
APA	Chen, Man-Man,&Meng, Ling-Hua.(2021).The double faced role of xanthine oxidoreductase in cancer.ACTA PHARMACOLOGICA SINICA,10.
MLA	Chen, Man-Man,et al."The double faced role of xanthine oxidoreductase in cancer".ACTA PHARMACOLOGICA SINICA (2021):10.