M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

doi:10.1186/s12951-021-01143-5

	M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors
	Wang,Yuqi 1,2; Gong,Xiang 2; Li,Jie 2; Wang,Hong 2; Xu,Xiaoxuan 2; Wu,Yao 2; Wang,Jiaoying 2; Wang,Siling 1; Li,Yaping 2; Zhang,Zhiwen 2,3
刊名	Journal of Nanobiotechnology
	2021-11-27
卷号	19 期号:1
关键词	Cancer stem cells Macrophage Microvesicle Nanoparticles Cabazitaxel
DOI	10.1186/s12951-021-01143-5
通讯作者	Wang,Siling(wangslsy@163.com) ; Li,Yaping(ypli@simm.ac.cn) ; Zhang,Zhiwen(zwzhang0125@simm.ac.cn)
英文摘要	AbstractCancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we herein designed M2 macrophage microvesicle-inspired nanovehicle of cabazitaxel (M-CFN) to promote accessibility to cancer cells and CSCs in tumors. In the 4T1 tumor model, M-CFN flexibly permeated the tumor mass, accessed cancer cells and CD90-positive cells, and significantly promoted their entry into CSC fractions in tumors. Moreover, M-CFN treatment profoundly eliminated aldehyde dehydrogenase (ALDH)-expressing CSCs in 4T1 and MCF-7 tumors, produced notable depression of tumor growth and caused 93.86% suppression of lung metastasis in 4T1 models. Therefore, the M2 macrophage microvesicle-inspired nanovehicle provides an encouraging strategy to penetrate the tumor tissues and access these insult cells in tumors for effective cancer therapy.Graphical Abstract
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12951-021-01143-5
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298803]
专题	中国科学院上海药物研究所
通讯作者	Wang,Siling; Li,Yaping; Zhang,Zhiwen
作者单位	1.Shenyang Pharmaceutical University; School of Pharmacy 2.Chinese Academy of Sciences; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica 3.Yantai Institute of Materia Medica; Yantai Key Laboratory of Nanomedicine & Advanced Preparations
推荐引用方式 GB/T 7714	Wang,Yuqi,Gong,Xiang,Li,Jie,et al. M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors[J]. Journal of Nanobiotechnology,2021,19(1).
APA	Wang,Yuqi.,Gong,Xiang.,Li,Jie.,Wang,Hong.,Xu,Xiaoxuan.,...&Zhang,Zhiwen.(2021).M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors.Journal of Nanobiotechnology,19(1).
MLA	Wang,Yuqi,et al."M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors".Journal of Nanobiotechnology 19.1(2021).